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citations
Cited by 87 publications
(69 citation statements)
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References 58 publications
(69 reference statements)
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“…In animal models, the presence or absence (and relevance) of hepatocyte ballooning is debated. It has been previously observed in mice and toxin-induced rat models of NASH (9,18), and in a recent elegant swine model of NASH (23); however, in our hands, as in others, the criteria according to the pathologist for ballooning were not met by simple but routine histochemical staining, agreeing with previous pathological examinations (40). A more detailed examination of hepatocyte ballooning, for example via K8/K18 immunostaining of liver sections, would be warranted to confirm this observation.…”
Section: Discussionmentioning
confidence: 77%
“…In animal models, the presence or absence (and relevance) of hepatocyte ballooning is debated. It has been previously observed in mice and toxin-induced rat models of NASH (9,18), and in a recent elegant swine model of NASH (23); however, in our hands, as in others, the criteria according to the pathologist for ballooning were not met by simple but routine histochemical staining, agreeing with previous pathological examinations (40). A more detailed examination of hepatocyte ballooning, for example via K8/K18 immunostaining of liver sections, would be warranted to confirm this observation.…”
Section: Discussionmentioning
confidence: 77%
“…Hypothetically, HCC might develope only from a small number of cells present in the cirrhotic liver, which are characterized by specific stem cell characteristics, such as suggested for the oval cell population. 48,49 In summary, the simultaneous analysis of about equal numbers of normal liver, cirrhotic liver and HCC with a novel, global tool assessing CpG islands allowed the delineation of distinct methylation patterns in cirrhotic and malignantly transformed liver suggesting a specific methylation biology of these processes. The origin of methylation stemness in HCC cannot, however, be finally clarified by our study-to pinpoint the clonal origins, further studies using HCC arising in noncirrhotic livers and the analysis of microdissected oval cell subpopulations will be necessary.…”
Section: Discussionmentioning
confidence: 99%
“…Case reports have also described patients with NASH who developed HCC without underlying cirrhosis [60,61] . Additionally, animal models have demonstrated a clear progression from NASH to cirrhosis and to cancer [62] . Although, in a smaller patient cohort, obesity significantly increased HCC [63] , a larger study including 1,145 patients failed to reproduce these findings [64] .…”
Section: Obesity Is a Risk Factor For Hccmentioning
confidence: 99%