Introduction of Relay Station (RS) is unavoidable and wireless RS has gained more interest for next generation mobile communication systems including Wireless Broadband (WiBro) system. Also, Multi-Input Multi-Output (MIMO) scheme is an emerging technology, offering high spectral efficiency. In this paper, we propose a system architecture applying Space Time Block Coding (STBC) algorithm in RS-Base Station (BS) link and Virtual MIMO (V-MIMO) scheme in Mobile Station (MS)-RS link based on WiBro network using wireless RS. The proposed system architecture is analyzed comparing with conventional single antenna system in uplink. As a result of simulation, the proposed system architecture outperforms the 2K3dB Bit Error Rate (BER) performance in RS-BS, MS-RS, MS-RS-BS uplink. And uplink transmission capacity improved 1.7-1.8 times. The system architecture proposed in this paper, is efficient because it can improve transmission gain and system capacity without change of MS.