“…The present series cannot provide any evidence regarding a possible correlation of Pringle maneuver with increased rate of leakage from colorectal anastomosis, and even previous literature has always failed to demonstrate this relationship [40,41]: On the other hand, the incidence of anastomotic leakage seems to be comparable with the rates reported in the series of colorectal surgery alone, even considering a significant representation of rectal cancers within present study [12][13][14][15]. In our experience, portal clamping do not have to be avoided on principle in cases of combined resections, but, in this setting, it should be used on demand to control intraoperative bleeding: Indeed, in contrast to what we argued about Pringle maneuver [42,43], a correlation between blood loss and clinical outcome has been demonstrated and any effort should be done to reduce the need for blood transfusions. The lower risk and In the present study, the laparoscopic approach was associated with longer operative time compared with open surgery (420 vs 310 min, respectively; p = 0.03), even though both colorectal and hepatic teams had already completed the learning curve once TLA was adopted at our institution: Longer length of surgery seemed not to have affected clinical outcome in terms of blood loss, functional recovery and morbidity.…”