A review: traditional herbs and remedies impacting pathogenesis of Parkinson’s disease

Sharma, Vishavdeep; Bedi, Onkar; Gupta, Manisha; Deshmukh, Rahul

doi:10.1007/s00210-022-02223-5

Cited by 4 publications

(2 citation statements)

References 165 publications

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“…Herbal products have gradually gained acceptance in treating neurodegenerative diseases for their multi-functional characteristic with relatively fewer adverse effects ( Wahid et al, 2020 ; Gregory et al, 2021 ; Wang et al, 2021 ). Herbal medicines have been applied to treat PD ( Chen et al, 2022 ; Sharma et al, 2022 ; Zahedipour et al, 2022 ), and GBE has proven efficacy. G. biloba , a medicinal plant belonging to the Ginkgoaceae family, is considered the oldest tree alive in the world ( Chen et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Yan

Wang

et al. 2022

Front. Pharmacol.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease with a fast-growing prevalence. Developing disease-modifying therapies for PD remains an enormous challenge. Current drug treatment will lose efficacy and bring about severe side effects as the disease progresses. Extracts from Ginkgo biloba folium (GBE) have been shown neuroprotective in PD models. However, the complex GBE extracts intertwingled with complicated PD targets hinder further drug development. In this study, we have pioneered using single-nuclei RNA sequencing data in network pharmacology analysis. Furthermore, high-throughput screening for potent drug-target interaction (DTI) was conducted with a deep learning algorithm, DeepPurpose. The strongest DTIs between ginkgolides and MAPK14 were further validated by molecular docking. This work should help advance the network pharmacology analysis procedure to tackle the limitation of conventional research. Meanwhile, these results should contribute to a better understanding of the complicated mechanisms of GBE in treating PD and lay the theoretical ground for future drug development in PD.

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Section: Discussionmentioning

confidence: 99%

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Yan

Wang

et al. 2022

Front. Pharmacol.

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“…Therefore, more studies have focused on herbal medicines and their extracts, which are considered to treat PD because of their good efficiency and hypotoxicity [7]. Sedum roseum (L.) Scop.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Salidroside for Parkinsonʼs Disease

Yao

2022

Planta Med

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Parkinson’s disease (PD), a neurological disorder, is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. Its incidence increases with age. Salidroside, a phenolic compound extracted from Sedum roseum, reportedly has multiple biological and pharmacological activities in the nervous system. However, its effects on PD remain unclear. In this review, we summarize the effects of salidroside on PD with regard to DA metabolism, neuronal protection, and glial activation. In addition, we summarize the susceptibility genes and their underlying mechanisms related to antioxidation, inflammation, and autophagy by regulating mitochondrial function, ubiquitin, and multiple signaling pathways involving NF-κB, mTOR, and PI3K/Akt. Although recent studies were based on animal and cellular experiments, this review provides evidence for further clinical utilization of salidroside for PD.

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Neuroprotective properties of the Lilium brownii extracts in the experimental model of Parkinson’s disease

Hui,

Jin,

et al. 2024

Metab Brain Dis

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A review: traditional herbs and remedies impacting pathogenesis of Parkinson’s disease

Cited by 4 publications

References 165 publications

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

The Therapeutic Potential of Salidroside for Parkinsonʼs Disease

Neuroprotective properties of the Lilium brownii extracts in the experimental model of Parkinson’s disease

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