A review on recent advances in application of electrospun nanofiber materials as biosensors

Liu, Yanbo; Hao, Ming; Chen, Zhijun; Liu, Lingling; Liu, Yao; Yang, Wenxiu; Ramakrishna, Seeram

doi:10.1016/j.cobme.2020.02.001

Cited by 96 publications

(52 citation statements)

References 54 publications

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“…The introduction of functional groups to the polymer solution before electrospinning eliminates further chemical modifications but increases the production complexity [ 29 ]. Once the desired electrospun paper is produced, it can be manipulated and integrated into a sensing platform in the same way as the typical paper is [ 7 ]. A more detailed explanation of the electrospinning process is presented in Section 4.1.2 , Electrospun mats.…”

Section: Paper and Fibrous Materials As A Complete Platform For Biosensorsmentioning

confidence: 99%

“…Moreover, the addition of carbon-based materials, metal and ceramic nanoparticles and functional polymers can produce fibers suitable to attach selectively sensing biomolecules, enhance conductivity in EC sensors, or improve colorimetric response [ 7 ]. In this regard, a wide number of publications can be found.…”

Section: Biosensor Fabricationmentioning

confidence: 99%

“…PADs usually comprise microfluidic, chemical, biochemical, and nano-composed components into paper or other fibrous substrates such as electrospun fibers. Since electrospun nanofibers materials are being extensively studied for biosensing applications [ 7 ], we defined a new category of fibrous biosensors called Electrospun Fiber-Based Biosensors (EFBs). Even though PADs and EFBs are intrinsically affordable, equipment-free, and deliverable to end-users, researchers still struggle to accomplish all the required criteria to produce devices capable of early diagnosis to enable immediate medical decisions making [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Paper and Other Fibrous Materials—A Complete Platform for Biosensing Applications

et al. 2021

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Paper-based analytical devices (PADs) and Electrospun Fiber-Based Biosensors (EFBs) have aroused the interest of the academy and industry due to their affordability, sensitivity, ease of use, robustness, being equipment-free, and deliverability to end-users. These features make them suitable to face the need for point-of-care (POC) diagnostics, monitoring, environmental, and quality food control applications. Our work introduces new and experienced researchers in the field to a practical guide for fibrous-based biosensors fabrication with insight into the chemical and physical interaction of fibrous materials with a wide variety of materials for functionalization and biofunctionalization purposes. This research also allows readers to compare classical and novel materials, fabrication techniques, immobilization methods, signal transduction, and readout. Moreover, the examined classical and alternative mathematical models provide a powerful tool for bioanalytical device designing for the multiple steps required in biosensing platforms. Finally, we aimed this research to comprise the current state of PADs and EFBs research and their future direction to offer the reader a full insight on this topic.

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Section: Paper and Fibrous Materials As A Complete Platform For Biosensorsmentioning

confidence: 99%

Section: Biosensor Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Paper and Other Fibrous Materials—A Complete Platform for Biosensing Applications

et al. 2021

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“…The filter was made adopting the polyethylene terephthalate (PET) for the outer layer deposition and the polivinilidenfluoruro (PVDF) for the nanomembrane inner layer, developed via electrospinning [ 30 ] (dimensions 1460 × 2031 × 1435 mm). This latter technology offers a higher resolution and great advantages in material processing over a wide range of applications, such as biosensors [ 31 ], tissue engineering [ 32 , 33 ], drug delivery [ 34 ], and supercapacitors [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Masks for Powders and Viruses Safety Protection Using Food Grade Polymers: Empirical Tests

Foresti

Ghezzi

Vettori³

et al. 2021

Polymers

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The production of 3D printed safety protection devices (SPD) requires particular attention to the material selection and to the evaluation of mechanical resistance, biological safety and surface roughness related to the accumulation of bacteria and viruses. We explored the possibility to adopt additive manufacturing technologies for the production of respirator masks, responding to the sudden demand of SPDs caused by the emergency scenario of the pandemic spread of SARS-COV-2. In this study, we developed different prototypes of masks, exclusively applying basic additive manufacturing technologies like fused deposition modeling (FDM) and droplet-based precision extrusion deposition (db-PED) to common food packaging materials. We analyzed the resulting mechanical characteristics, biological safety (cell adhesion and viability), surface roughness and resistance to dissolution, before and after the cleaning and disinfection phases. We showed that masks 3D printed with home-grade printing equipment have similar performances compared to the industrial-grade ones, and furthermore we obtained a perfect face fit by customizing their shape. Finally, we developed novel approaches to the additive manufacturing post-processing phases essential to assure human safety in the production of 3D printed custom medical devices.

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“…Zhang et al 21 fabricated polycaprolactone membranes by electrodeposition and later added methyl silicone oil and hydrophobic nanoparticles to obtain a water contact angle of 151.6 ± 1.7 and a sliding angle of 7.4 ± 1.2 . A good number of reviews are also available on various aspects of ES, such as polymer nanofibers, 22 methods and applications, 23 biopolymer nanofibers, 24 tunable wettability of electrospun mats, 25 fabrication of membranes for water treatment applications, 26 electrospun nanofibers for food packaging, 27 optical sensors, 28 biosensors, 29 and so on. Recently, Prabu and Bhaarathi 30 reported on the novel multipin electrospinning system for encapsulation of nanoparticles into nanofibers which clearly shows that electrospinning remains as an interesting field of research over the past six decades after Formhals patented the primitive electrospinning system in 1939.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of superhydrophobic and self cleaningPVA‐silicafiber coating on304L SSsurfaces by electrospinning

Vanithakumari

Athulya

George

et al. 2020

J of Applied Polymer Sci

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In this work superhydrophobic coating with self cleaning property is fabricated on 304L SS samples directly using a simple one step electrospinning process followed by silane treatment by using polyvinyl alcohol (PVA) and tetraethyl orthosilicate solution. A maximum water contact angle of 169.2 ± 2.1 is obtained at an electrospinning potential of 15 kV for 2 h, with a distance of 18 cm between the collector and needle. The hierarchical nanostructures thus formed on 304L SS composed of poly(vinyl alcohol)-silica microbeads and nanofibers. The surface morphologies are optimized by varying the electrospinning voltage, time, distance between needle and the collector and aging duration of the precursors. Attenuated total reflectance-infrared spectroscopy studies at different stages of preparation confirmed the presence of PVA/SiO 2 composite nanofibers deposited on the 304L SS surface. The reaction of SiO 2 nanofibers with hexamethyl disilazane resulted in the formation of Si O Si bonds that provided water repellent property. The developed SHP surface coating on 304L SS sample showed dynamic bouncing of water droplets and excellent self cleaning performance. The sample retained the SHP behavior in chloride solutions with different ionic strengths and pH.

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A review on recent advances in application of electrospun nanofiber materials as biosensors

Cited by 96 publications

References 54 publications

Paper and Other Fibrous Materials—A Complete Platform for Biosensing Applications

Paper and Other Fibrous Materials—A Complete Platform for Biosensing Applications

3D Printed Masks for Powders and Viruses Safety Protection Using Food Grade Polymers: Empirical Tests

Fabrication of superhydrophobic and self cleaningPVA‐silicafiber coating on304L SSsurfaces by electrospinning

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