A Review on Nanosuspension Technology in Drug Delivery System

Abstract

Nanosuspension can be defined as colloidal dispersions of Nano-sized drug particles that are produced by a suitable method and stabilized by a suitable stabilizer. They can also define as the biphasic system consisting of pure drug particle dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1µm in size. Techniques of drug Nanosuspension preparation can be categorized into two principle classes; Top-down and bottom-up technologies. The top-down technologies are the mechanical communication processes of larger drug particles, as in milling and homogenization. The bottom-up technologies begin with the molecules which are dissolved and then precipitated through on solvent addition a in supercritical fluid technology, spray freezing in to liquid process, evaporative precipitation into aqueous solution and liquid solvent change process. Although top-down approaches are widely employed, the drawbacks associated with mechanical attritions processes, such as time consumption, intensive energy use, inadequate control of particles size and electrostatic effects, promote greater interest toward bottom up creation of nanoparticles. Nano means it is the factor of 10 -9 . The particle size distribution ranges from 0.1µm to 25µm, only negligible amount being below 1µm in the manometer range. For a long duration of time micronization of poorly soluble drugs by colloidal mills was prepared. Different Methods for Preparation of Nanosuspension [1]Mainly there are two methods for preparation of Nanosuspension. The conventional methods of precipitation are called Bottom up Technology. In Bottom up Technology the drug is dissolved in a solvent, which is then added to non-solvent to precipitate the crystal. This technique is that during the precipitation procedure the growing of the drug crystals need to be controlled by addition of surfactant to avoid formation of micro particles. The top down Technologies are the disintegration methods and are preferred over the precipitation methods. The top

Review on Nanosuspension as a Novel Method for Solubility and Bioavailability Enhancement of Poorly Soluble Drugs

“…With this technique, it is possible to produce stable amorphous nanocrystals and reduce the particle size to the submicron range. One of the advantages of this method is that it increases physicochemical properties due to altered surface properties and the drug's transformation from crystalline to amorphous form [10,34].…”