A review on chitosan-based biomaterial as carrier in tissue engineering and medical applications

Wang, Lanqing; Xu, Zhenghong; Zhang, Han; Yao, Chung-Chen Jane

doi:10.1016/j.eurpolymj.2023.112059

Cited by 13 publications

(7 citation statements)

References 138 publications

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“…It has also been shown that chitosan has antibacterial properties by acting on the cytoplasmic membrane of bacterial cells. These properties make chitosan useful in medicine and various industries [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Sierakowska-Byczek,

Radwan-Pragłowska,

Janus

et al. 2024

Polymers

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Tissue engineering constitutes the most promising method of severe peripheral nerve injuries treatment and is considered as an alternative to autografts. To provide appropriate conditions during recovery special biomaterials called nerve guide conduits are required. An ideal candidate for this purpose should not only be biocompatible and protect newly forming tissue but also promote the recovery process. In this article a novel, multilayered biomaterial based on polyvinylpyrrolidone, collagen and chitosan of gradient structure modified with conductive nanoparticles is presented. Products were obtained by the combination of electrospinning and electrospraying techniques. Nerve guide conduits were subjected to FT-IR analysis, morphology and elemental composition study using SEM/EDS as well as biodegradation. Furthermore, their effect on 1321N1 human cell line was investigated by long-term cell culture. Lack of cytotoxicity was confirmed by XTT assay and morphology study. Obtained results confirmed a high potential of newly developed biomaterials in the field of nerve tissue regeneration with a special focus on injured nerves recovery.

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Section: Introductionmentioning

confidence: 99%

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Sierakowska-Byczek,

Radwan-Pragłowska,

Janus

et al. 2024

Polymers

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“…Chitin (Figure 1a) is made of >50% GlcNAc units (i.e., %DA > 50%), while chitosan (Figure 1b) is made of >50% GlcN units (i.e., %DA < 50%); the similarities of these two polymers to the structure of GAGs are shown in Figure 1c. Chitosan applications in the TE area are well documented and numerous reviews cover the use of chitosan in regenerative medicine [11,12]. However, the biological properties of chitin and chitosan differ.…”

Section: Introductionmentioning

confidence: 99%

“…Chitin also plays a vital role in bone mineralization, for bone repair (i.e., in chitin-calcium phosphate composites). Chitosan applications in the TE area are well documented and numerous reviews cover the use of chitosan in regenerative medicine [11,12]. However, the biological properties of chitin and chitosan differ.…”

Section: Introductionmentioning

confidence: 99%

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Design of Chitin Cell Culture Matrices for 3D Tissue Engineering: The Importance of Chitin Types, Solvents, Cross-Linkers, and Fabrication Techniques

Basak,

Shamshina

2024

Pharmaceutics

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This review focuses on factors and the fabrication techniques affecting the microarchitecture of tissue engineering scaffolds from the second most abundant biopolymer, chitin. It emphasizes the unique potentiality of this polymer in tissue engineering (TE) applications and highlights the variables important to achieve tailored scaffold properties. First, we describe aspects of scaffolds’ design, and the complex interplay between chitin types, solvent systems, additives, and fabrication techniques to incorporate porosity, with regard to best practices. In the following section, we provide examples of scaffolds’ use, with a focus on in vitro cell studies. Finally, an analysis of their biodegradability is presented. Our review emphasizes the potentiality of chitin and the pressing need for further research to overcome existing challenges and fully harness its capabilities in tissue engineering.

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“…There is great research interest in chitosan because of its unique properties, which are non-toxicity, biocompatibility, biodegradability, and antibacterial and antioxidant activity, in addition to being a derivative of a natural polymer, chitin, which is considered the second natural polymer after cellulose [1,2]. These properties make it and its derivatives prevalent in many applications, such as adsorbents for pollutants in wastewater treatment, packaging materials, cosmetics, antioxidant, and antibacterial agents, as well as in the biomedical healthcare fields, including wound healing, scaffolds for tissue engineering, drug delivery systems, and antitumor chemotherapy [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

New Functionalized Chitosan with Thio-Thiadiazole Derivative with Enhanced Inhibition of Pathogenic Bacteria, Plant Threatening Fungi, and Improvement of Seed Germination

et al. 2023

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In this study, a new modified chitosan conjugate (Chito-TZ) was developed via amide coupling between the acid chloride derivative of the methylthio-thidiazole compound and the free primary amino groups of chitosan. The product was characterized using several instrumental investigations, including Fourier-transform infrared spectroscopy (FT-IR), 1H-Nuclear magnetic resonance, X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). XRD indicated that the crystalline pattern of chitosan was interrupted after chemical modification with the thiadiazole derivative. Broido’s model was used to determine the thermal activation energy Ea, and the results showed that the Ea for the first decomposition region of Chito-TZ is 24.70 KJ mol−1 lower than that required for chitosan (95.57 KJ mol−1), indicating the accelerating effect of the thiadiazole derivative on the thermal decomposition of Chito-TZ. The modified chitosan showed better antibacterial and antifungal activities than the non-modified chitosan; except for seed germination, chitosan was better. The Chito-TZ showed a low MIC value (25–50 µg mL−1) compared to Chito (50–100 µg mL−1). Moreover, the maximum inhibition percentages for plant-pathogenic fungi, Aspergillus niger, Fusarium oxysporum, and Fusarium solani, were attained at a concentration of 300 µg mL−1 with values of 35.4 ± 0.9–39.4 ± 1.7% for Chito and 45.2 ± 1.6–52.1 ± 1.3% for Chito-TZ. The highest germination percentages (%) of broad bean, shoot and root length and weight, and seed vigor index were obtained after Chito treatment with a concentration of 200 µg mL−1 compared to Chito-TZ.

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A review on chitosan-based biomaterial as carrier in tissue engineering and medical applications

Cited by 13 publications

References 138 publications

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Design of Chitin Cell Culture Matrices for 3D Tissue Engineering: The Importance of Chitin Types, Solvents, Cross-Linkers, and Fabrication Techniques

New Functionalized Chitosan with Thio-Thiadiazole Derivative with Enhanced Inhibition of Pathogenic Bacteria, Plant Threatening Fungi, and Improvement of Seed Germination

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