2018
DOI: 10.3389/fphar.2018.00024
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Abstract: Rhizoma Gastrodiae (also known as Tian ma), the dried rhizome of Gastrodia elata Blume, is a famous Chinese herb that has been traditionally used for the treatment of headache, dizziness, spasm, epilepsy, stoke, amnesia and other disorders for centuries. Gastrodin, a phenolic glycoside, is the main bioactive constituent of Rhizoma Gastrodiae. Since identified in 1978, gastrodin has been extensively investigated on its pharmacological properties. In this article, we reviewed the central nervous system (CNS) eff… Show more

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Cited by 156 publications
(132 citation statements)
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References 101 publications
(110 reference statements)
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“…In addition, alkaloids of Uncariae Ramulus Cum Uncis [including isocorynoxeine (P15), isorhynchophylline (P16), rhynchophylline (P17), corynoxeine (P19), hirsuteine (P28) and hirsutine (P30)] have been demonstrated to be the predominant pharmacological active components, which can pass the blood–brain barrier (Zhang, Yang, Xu, & Yang, ). Gastrodiae Rhizoma has been traditionally used for the treatment of headache, dizziness, spasm, epilepsy, stroke, amnesia and other disorders, owing to its main bioactive constituent gastrodin (P1), which possesses a broad range of beneficial effects on central nervous system diseases (Liu et al, ). The major phytochemicals isolated from Scutellariae Radix are flavonoids, glycosides and their glucuronides such as baicalin (P18), baicalein (P29) and wogonin (P32).…”
Section: Resultsmentioning
confidence: 99%
“…In addition, alkaloids of Uncariae Ramulus Cum Uncis [including isocorynoxeine (P15), isorhynchophylline (P16), rhynchophylline (P17), corynoxeine (P19), hirsuteine (P28) and hirsutine (P30)] have been demonstrated to be the predominant pharmacological active components, which can pass the blood–brain barrier (Zhang, Yang, Xu, & Yang, ). Gastrodiae Rhizoma has been traditionally used for the treatment of headache, dizziness, spasm, epilepsy, stroke, amnesia and other disorders, owing to its main bioactive constituent gastrodin (P1), which possesses a broad range of beneficial effects on central nervous system diseases (Liu et al, ). The major phytochemicals isolated from Scutellariae Radix are flavonoids, glycosides and their glucuronides such as baicalin (P18), baicalein (P29) and wogonin (P32).…”
Section: Resultsmentioning
confidence: 99%
“…Gastrodin (GAS), the glucoside of HBA, is the major bioactive ingredient that can be isolated from GEB. In East Asian countries, the dried rhizomes of GEB have been widely used for centuries to treat many neurological or psychiatric disorders including convulsive disorders, dizziness, dementia, depression, and migraines [3]. Increasing research is being conducted to determine the underlying molecular mechanisms through which the active constituents of GEB may exert their pharmaceutical effects.…”
Section: Introductionmentioning
confidence: 99%
“…GAS has been demonstrated to penetrate the blood-brain barrier, and it has been suggested that it may produce neuroprotective effects against hypoxia, oxidative injuries, or glutamate induced excitotoxicity [4][5][6]. Recent studies have also provided evidence of its antiepileptic, anxiolytic, free-radical scavenging, anti-inflammatory, and anti-obesity actions [3,7]. After entering the central nervous system, GAS is metabolized to HBA [8].…”
Section: Introductionmentioning
confidence: 99%
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