A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera

Gerometta, Elise; Grondin, Isabelle; Smadja, Jacqueline; Frédérich, Michel; Gauvin‐Bialecki, Anne

doi:10.1016/j.jep.2020.112608

Cited by 50 publications

(37 citation statements)

References 242 publications

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“…Several other molecules, like Aconine extracted from ( Aconiti Lateralis Radix Preparata ) a Chinese medicinal plant, inhibits the expression of DCs, RANK‐L induced activation of NF‐κB and NFTc1 in RAW 264.7 cells (Zeng et al, 2016). Indigofera species contain a mixture of compounds including isatin, indigo, indirubin with a wide range of pharmacological activities, please also refer to the review for more information (Gerometta, Grondin, Smadja, Frederich, & Gauvin‐Bialecki, 2020). For example, indigo obtained from Indigofera suffruticosa significantly stimulated immune responses by inducing nitric oxide (NO) production, TNF‐α release and enhances macrophage function (Lopes, Calvo, Colombo, Vilegas, & Carlos, 2011).…”

Section: Plants As Biological Sources For Immunomodulatorsmentioning

confidence: 99%

Potential therapeutic applications of phytoconstituents as immunomodulators: Pre‐clinical and clinical evidences

Ali

Singh

Datusalia

2021

Phytotherapy Research

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Autoimmune and infectious diseases are the major public health issues and have gained great attention in the last few years for the search of new agents with therapeutic benefits on the host immune functions. In recent years, natural products (NPs) have been studied broadly for their multi-targeted activities under pathological conditions. Interestingly, several attempts have been made to outline the immunomodulatory properties of NPs. Research on in-vitro and in-vivo models have shown the immunomodulatory activity of NPs, is due to their antiinflammatory property, induction of phagocytosis and immune cells stimulation activity. Moreover, studies on humans have suggested that phytomedicines reduce inflammation and could provide appropriate benefits either in single form or complex combinations with other agents preventing disease progression, subsequently enhancing the efficacy of treatment to combat multiple malignancies.However, the exact mechanism of immunomodulation is far from clear, warranting more detailed investigations on their effectiveness. Nevertheless, the reduction of inflammatory cascades is considered as a prime protective mechanism in a number of inflammation regulated autoimmune diseases. Altogether, this review will discuss the biological activities of plant-derived secondary metabolites, such as polyphenols, alkaloids, saponins, polysaccharides and so forth, against various diseases and their potential use as an immunomodulatory agent under pathological conditions.

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Section: Plants As Biological Sources For Immunomodulatorsmentioning

confidence: 99%

Potential therapeutic applications of phytoconstituents as immunomodulators: Pre‐clinical and clinical evidences

Ali

Singh

Datusalia

2021

Phytotherapy Research

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“…Indigofera species comprise mainly herbs, perennial or annual, shrubs or small-sized trees, distributed in forests, savannas, and disturbed areas (Marquiafável et al 2009;Gerometta et al 2020). The lifespan of Indigofera tinctoria L. as a dye producer is 2-3 years (Kurniawan 2020;Ariyanti and Asbur 2018), whereas if it only functions as a land cover it is 1.5-2 years (Kurniawan 2020).…”

Section: Introductionmentioning

confidence: 99%

The Development of Indigofera spp. as a Source of Natural Dyes to Increase Community Incomes on Timor Island, Indonesia

Agustarini¹,

Heryati²,

Adalina³

et al. 2022

Economies

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A strategy that has the potential to contribute to the achievement of the targets established under SDG 8 (“Decent Work and Economic Growth”) involves the development of sustainable tourism to create productive job and livelihood opportunities and to promote local culture and products. In the province of East Nusa Tenggara (NTT), Indonesia, ikat weaving is an integral part of the cultural heritage of the region, with ikat characterized by unique design motives and the use of natural dyes. Unfortunately, in some areas, the use of natural dyes is diminishing as a result of competition with synthetic dyes and the limited availability of raw materials, particularly for the production of blue dye. The development of Indigofera spp. to produce natural, plant-based blue dye has significant potential to contribute to community incomes and employment. This study outlines a strategy for developing the use of Indigofera spp. as a natural dye and describes its potential for contributing to community incomes, especially on Timor Island, NTT. The study shows that weavers currently use indigo plants that grow naturally in gardens and yards. Although the community has a tradition of using these plants, informed by local wisdom, to develop the cultivation and processing of this plant through the application of the appropriate techniques, including innovative approaches to producing indigo paste, could enable the development of Indigofera spp. cultivation on a larger scale. The study shows that the availability of suitable land is high (±370 thousand ha), with 80% of the suitable land being categorized as critical. The study proposes a development based on the analysis of strengths, weaknesses, opportunities, and threats to assess the manner in which these opportunities could be leveraged with the support and participation of local communities and other stakeholders by leveraging the culture and wisdom of the community regarding the use of Indigofera spp.

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“…Indigofera is the third‐largest genus of Fabaceae family and papilionacea subfamily, with more than 750 species known. Most of its species are grown and adaptable to a range of climates in the tropics and subtropics as herbal medicine and for indigo dye production (Gerometta et al., 2020). The pigment indigo is extracted from the leaves and stems of 14 indigofera species (Ansori et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, indigo is used in constipation, liver disease, heart palpitation, and gout (Perry & Metzger, 1980). In traditional medicine, it is used to treat some diseases, for example, gastrointestinal disorders, skin ailments, and respiratory and infectious diseases (Gerometta et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of growth and yield of indigo ecotypes in different sowing dates and genetic diversity analysis using AFLP markers

2022

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Indigo (Indigoferatinctoria L.), as a forgotten crop, has immense industrial and medicinal value. In this research, the effect of sowing date on the leaf, seed, and dye yield of indigo was examined at Jiroft, Iran, during the 2013 and 2014 growing seasons. The experiment was arranged as a split-plot based on a randomized complete block design with three replications. Planting dates (5 May, 20 May, and 5 June) and indigo ecotypes as landraces of Jiroft, Roudbar, Rigan, and Ghale-ganj were considered as main and subplots, respectively, aiming to evaluate their effects on pod number/plant, 1,000-seed weight, seed number/pod, leaf dry weight, seed yield, as well as indigo dye percentage and yield. The results indicated that the indigo content was greater at the second sowing date (0.68%) than the first (0.66%) and third (0.65%) dates. Further, the indigo percentage was greater in Jiroft and Roudbar ecotypes compared with Rigan and Ghale-ganj. Seed yield at the second and third sowing dates significantly increased (560.3 kg ha -1 ) and reduced (188.4 kg ha -1 ), respectively, compared with the first sowing date (261.4 kg ha -1 ). Furthermore, the highest value of leaf dry weight, indigo yield, and seed yield were obtained from the Jiroft ecotype at the second sowing date; in contrast, the lowest of these parameters were recorded in the Ghale-ganj ecotype at the latest sowing date. Moreover, the genetic diversity of ecotypes was studied using the amplified fragment length polymorphism (AFLP) marker. Based on the dendrogram, the four ecotypes of indigo were divided into three groups; thus, Jiroft and Rudbar, geographically close to each other and almost the same, were in one group, and Reagan and Ghale-Ganj were in separate groups. Overall, based on this research results, Jiroft and 20 May could be suggested as the best ecotype and sowing date of indigo for the examined region. Obtained results can also be useful for expanding and facilitating the cultivation of neglected plants. INTRODUCTIONIndigo (Indigofera tinctoria L.), as a forgotten crop, is one of the blue dyes used for the textile industry (Abbas Uddin Abbreviations: AFLP, amplified fragment lenth polymorphism; GDD, growing degree days.

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A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera

Cited by 50 publications

References 242 publications

Potential therapeutic applications of phytoconstituents as immunomodulators: Pre‐clinical and clinical evidences

Potential therapeutic applications of phytoconstituents as immunomodulators: Pre‐clinical and clinical evidences

The Development of Indigofera spp. as a Source of Natural Dyes to Increase Community Incomes on Timor Island, Indonesia

Evaluation of growth and yield of indigo ecotypes in different sowing dates and genetic diversity analysis using AFLP markers

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