A Review of the Structure, Pharmacokinetics, Pharmacodynamics, Efficacy
and Safety of Insulin Glulisine in the Management of Diabetes
Mellitus
Abstract:Glulisine (Apidra TM) is a rapid acting recombinant insulin analogue which differs from regular human insulin (RHI) by the substitution of lysine for asparagine at position B3 and glutamic acid for lysine at position B29. The chemical name is 3B-Lys-29-B-Glu-human insulin.The amino acid substitutions of glulisine and other rapid acting insulin analogues promote monomer stability, allowing for rapid dissociation and absorption after subcutaneous injection. It has a favourable pharmacokinetic and pharmacodynamic… Show more
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