2018
DOI: 10.1186/s12974-018-1387-y
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Abstract: Ischemic stroke starts a series of pathophysiological processes that cause brain injury. Caveolin-1 (cav-1) is an integrated protein and locates at the caveolar membrane. It has been demonstrated that cav-1 can protect blood–brain barrier (BBB) integrity by inhibiting matrix metalloproteases (MMPs) which degrade tight junction proteins. This article reviews recent developments in understanding the mechanisms underlying BBB dysfunction, neuroinflammation, and oxidative stress after ischemic stroke, and focuses … Show more

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Cited by 62 publications
(45 citation statements)
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“…However, how cystatin C down‐regulates MMP‐9 activity remains unclear. Several studies have reported that caveolin‐1 can protect BBB integrity by inhibiting MMPs, especially MMP‐9 (Gu et al ; Choi et al ; Huang et al ), and recently, we found that cystatin C up‐regulates caveolin‐1 in cerebral I/R injury. These results suggest that cystatin C might promote the inhibition of MMP‐9 by up‐regulating caveolin‐1, contributing to its neuroprotective effect on BBB disruption in acute cerebral I/R injury.…”
Section: Discussionsupporting
confidence: 64%
See 1 more Smart Citation
“…However, how cystatin C down‐regulates MMP‐9 activity remains unclear. Several studies have reported that caveolin‐1 can protect BBB integrity by inhibiting MMPs, especially MMP‐9 (Gu et al ; Choi et al ; Huang et al ), and recently, we found that cystatin C up‐regulates caveolin‐1 in cerebral I/R injury. These results suggest that cystatin C might promote the inhibition of MMP‐9 by up‐regulating caveolin‐1, contributing to its neuroprotective effect on BBB disruption in acute cerebral I/R injury.…”
Section: Discussionsupporting
confidence: 64%
“…Thus, we sought to elucidate the effect of cystatin C on regulating BBB integrity in acute ischemic brain injury and to reveal the interaction between cystatin C and caveolin‐1 in acute ischemic brain tissues. Caveolin‐1 has previously been shown to be critical for decreasing endothelial tight junction permeability by up‐regulating tight junction proteins in ischemic cerebral injury (Huang et al ). Our present data provide potential mechanistic insight into how cystatin C regulates caveolin‐1 through the up‐regulation of occludin and ultimately increases neuronal survival in cerebral I/R injury.…”
Section: Discussionmentioning
confidence: 99%
“…In the brain, caveolin-1 is primarily expressed in endothelial cells, pericytes, and astroglial cells, and caveolin-1 can regulate neuronal signaling and promote dendritic growth [23]. Changes in caveolin-1 can cause a series of changes in BBB permeability, neuroin ammation, oxidative stress, apoptosis, neurogenesis and angiogenesis [24]. Previous reports have suggested that caveolin-1 can regulate MMP-9.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies had confirmed the Blood-brain barrier (BBB) dysfunction caused by epilepsy (20,21), which may provide a promotion of extravasation of brain-specific proteins into peripheral blood (22). Caveolin-1 (CAV1) is an integral membrane protein, mainly expressed in vessels in the CNS (23) and play an important role in protection of BBB (24). In the study conducted by Liu et al the CAV-1 increased with the BBB hyperpermeability in three mainstream BBB dysfunctional model in vivo (25).…”
Section: Introductionmentioning
confidence: 98%