A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease

Ma, Yan; Cai, Fei; Li, Yangyang; Chen, Jianghua; Han, Fei; Lin, Weiqiang

doi:10.1016/j.bioactmat.2020.05.002

Cited by 60 publications

(51 citation statements)

References 126 publications

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“…Targeting kidney via nanoparticles is due to their unique properties via tailoring size, shape, charge and ligands. Moreover, nanoparticles are promising tools of fabricating implantable artificial kidneys [ 55 ]. Exposure to different classes of nanoparticles may have undesirable effects on cells and organs.…”

Section: Kidney-targeted Delivery Systemsmentioning

confidence: 99%

Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration

et al. 2021

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The implementation of nanomedicine not only provides enhanced drug solubility and reduced off-target adverse effects, but also offers novel theranostic approaches in clinical practice. The increasing number of studies on the application of nanomaterials in kidney therapies has provided hope in a more efficient strategy for the treatment of renal diseases. The combination of biotechnology, material science and nanotechnology has rapidly gained momentum in the realm of therapeutic medicine. The establishment of the bedrock of this emerging field has been initiated and an exponential progress is observed which might significantly improve the quality of human life. In this context, several approaches based on nanomaterials have been applied in the treatment and regeneration of renal tissue. The presented review article in detail describes novel strategies for renal failure treatment with the use of various nanomaterials (including carbon nanotubes, nanofibrous membranes), mesenchymal stem cells-derived nanovesicles, and nanomaterial-based adsorbents and membranes that are used in wearable blood purification systems and synthetic kidneys.

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Section: Kidney-targeted Delivery Systemsmentioning

confidence: 99%

Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration

et al. 2021

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“…Indeed, research has shown that NPs with sizes of approximately 75 ± 25 nm targeted the renal mesangium, whereas larger NPs (>100 nm) could not pass the glomerular filter. Consequently, studies focusing on targeting renal tubule cells have designed NPs smaller than 10 nm, allowing them to pass the glomerular filtration barrier and be internalized by the epithelial cells [ 133 ]. Similarly, Han et al [ 134 ] postulated that nanoparticles smaller than 250 nm tend to accumulate in the liver and spleen.…”

Section: Overcoming Delivery Problemsmentioning

confidence: 99%

“…This includes the use of targeting ligands, such as antibodies or aptamers [ 4 , 59 , 131 ]. Indeed, several ligands such as E-selectin antibody, Ac2-26 peptide, cyclopeptide, or angiotensin I/II have been already employed to target their corresponding receptors in mesangial cells, podocytes or tubular cells [ 133 ]. Interestingly, the use of small molecules as ligands has also been evaluated.…”

Section: Overcoming Delivery Problemsmentioning

confidence: 99%

Oligonucleotide-Based Therapies for Renal Diseases

et al. 2021

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The global burden of chronic kidney disease (CKD) is increasing every year and represents a great cost for public healthcare systems, as the majority of these diseases are progressive. Therefore, there is an urgent need to develop new therapies. Oligonucleotide-based drugs are emerging as novel and promising alternatives to traditional drugs. Their expansion corresponds with new knowledge regarding the molecular basis underlying CKD, and they are already showing encouraging preclinical results, with two candidates being evaluated in clinical trials. However, despite recent technological advances, efficient kidney delivery remains challenging, and the presence of off-targets and side-effects precludes development and translation to the clinic. In this review, we provide an overview of the various oligotherapeutic strategies used preclinically, emphasizing the most recent findings in the field, together with the different strategies employed to achieve proper kidney delivery. The use of different nanotechnological platforms, including nanocarriers, nanoparticles, viral vectors or aptamers, and their potential for the development of more specific and effective treatments is also outlined.

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“…A significant number of applications in nanophotonics depend on the nanoparticles’ geometry, and material composition [ 13 , 14 , 15 , 16 , 17 ]. Metallic nanoparticles have attracted great interest in biomedical applications due to their optical, electrical, and magnetic properties as a function of their size and morphology which can be tuned during the synthesis process [ 18 , 19 , 20 , 21 ]. A special case is gold nanoparticles, that exhibit unique properties used in biomedical applications [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Computational and Experimental Analysis of Gold Nanorods in Terms of Their Morphology: Spectral Absorption and Local Field Enhancement

et al. 2021

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A nanoparticle’s shape and size determine its optical properties. Nanorods are nanoparticles that have double absorption bands associated to surface plasmon oscillations along their two main axes. In this work, we analize the optical response of gold nanorods with numerical simulations and spectral absorption measurements to evaluate their local field enhancement—which is key for surface-enhanced Raman spectroscopic (SERS) applications. Our experimental results are in good agreement with finite element method (FEM) simulations for the spectral optical absorption of the nanoparticles. We also observed a strong dependence of the optical properties of gold nanorods on their geometrical dimension and shape. Our numerical simulations helped us reveal the importance of the nanorods’ morphology generated during the synthesis stage in the evaluation of absorption and local field enhancement. The application of these gold nanorods in surface-enhancement Raman spectroscopy is analyzed numerically, and results in a 5.8×104 amplification factor when comparing the values obtained for the nanorod deposited on a dielectric substrate compared to the nanorod immersed in water.

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A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease

Cited by 60 publications

References 126 publications

Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration

Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration

Oligonucleotide-Based Therapies for Renal Diseases

Computational and Experimental Analysis of Gold Nanorods in Terms of Their Morphology: Spectral Absorption and Local Field Enhancement

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