A REVIEW OF SOME RECENT INVESTIGATIONS IN THE QUINAZOLINE GROUP.²

Abstract

IKCANIC A S D BIOLOGIC.\I.being soon recognized. Soxhlet especially devoted much of his tinie to the study of the method and established' the exact conditions under which the determination must be carried out in order to get satisfactory results.

ChemInform Abstract: Fused‐Skeleton Saturated Six‐Membered 1,3‐N,O, N,N and N,S Heterocycles. Fused‐Skeleton Aryl‐Substituted Saturated Isoindolones

“…lsoxazolines (23a,b), prepared from cyclopentene or cyclohexene and in situ benzonitrile oxide, were reduced with lithium aluminium hydride (LAH) to the aminoalcohols (24a, b). (83987) The diastereomeric aminoalcohol (25) was prepared by reduction with sodium in ethanol. Aminoalcohols (24b) and (25) were cyclized with imidates to diastereomeric fused-skeleton dihydrooxazines (26a,b) and (27).…”

“…(83987) The diastereomeric aminoalcohol (25) was prepared by reduction with sodium in ethanol. Aminoalcohols (24b) and (25) were cyclized with imidates to diastereomeric fused-skeleton dihydrooxazines (26a,b) and (27). With ethyl chloroformate and sodium ethoxide, the 1,3-oxazin-2-ones (28a) and (28b) were prepared, while the corresponding thiones (29a) and (29b) were obtained with carbon disulphide and lead(l1) nitrate.…”

“…For example, the benzoxazinones were described in 1 909, (21) but the syntheses of saturated analogues of the benzoxazinones and their homologues saturated in the carbocycle were reported by us only some 70 years The first synthesis of quinazolinones was published in 1910 (25) and wideranging research was carried out on these heterocycles from both scientific and industrial points of view, (26) but the first stereohomogeneous cis-and trans-tetramethylene-condensed saturated pyrimidinones were described by Armarego,(2n author of the monograph "Quinazolinones" in "Fused Pyrimidines" (26) in the well-known Weissberger series.…”

Sunflower Assisted Bio-derived ZnO-NPs as an Efficient Nanocatalyst for Synthesis of Novel Quinazolines with Highly Antioxidant Activities

“…In recent years, the synthesis of six membered quinazoline heterocycles and its derivatives Fig. 1 has become attractive in synthetic organic chemistry due to their broad biological and medicinal activities [17][18] [38] are such methods for the preparation of 1,2-dihydroquinazolines. However, these methods suffer from limitations such as, harsh reaction conditions, expensive reagents, difficult purification procedures, lesser product yields, metal catalysts as well as more than stoichiometric amount of reagents.…”

An Overview of Ag‐catalyzed Synthesis of Six‐membered Heterocycles

“…The NADP/NADPH redox system and diverse alkaloids such as nicotine contain pyridine, a six‐membered heterocycle [10] . Isocoumarins [11,12] and quinazolines [13,14] are known for their excellent biological activities. Some of the important pharmaceutically relevant six‐membered heterocyclic compounds are displayed (Figure 2).…”