A review of remote ischemic conditioning as a potential strategy for neural repair poststroke

Abstract

Ischemic stroke is one of the major disabling health‐care problem and multiple different approaches are needed to enhance rehabilitation, in which neural repair is the structural basement. Remote ischemic conditioning (RIC) is a strategy to trigger endogenous protect. RIC has been reported to play neuroprotective role in acute stage of stroke, but the effect of RIC on repair process remaining unclear. Several studies have discovered some overlapped mechanisms RIC and neural repair performs. This review provides a hypothesis that RIC is a potential therapeutic strategy on stroke rehabilitation by evaluating the existing evidence and puts forward some remaining questions to clarify and future researches to be performed in the field.

Hypoxic Preconditioning Modulates BDNF and Its Signaling through DNA Methylation to Promote Learning and Memory in Mice

“…Especially, remote ischemic conditioning, one of the types of HPC, has a significant contribution to neural repair after stroke in clinical practice. 37 However, the design of drugs targeting DNA methylation and BDNF signaling may also be one of the therapeutic treatments for neurological diseases. Drugs and Intracerebroventricular Injection.…”

“…As many neurological hypoxia/ischemia diseases such as stroke, epilepsy, and depression are characterized by cognitive dysfunction and associated with epigenetic changes and downregulation of BDNF, HPC may have a preventive effect on these disorders through the above-mentioned pathways. Especially, remote ischemic conditioning, one of the types of HPC, has a significant contribution to neural repair after stroke in clinical practice . However, the design of drugs targeting DNA methylation and BDNF signaling may also be one of the therapeutic treatments for neurological diseases.…”