1982
DOI: 10.1177/106002808201600908
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Abstract: Many containers for intravenous solutions are made with plasticized polyvinyl chloride, the common form of which is di-2-ethylhexylphthalate (DEHP). Extraction of DEHP into blood and plasma stored in such plastic containers can occur, and harmful effects of DEHP in the human body consequently have been suggested. Reports on toxicity of DEHP in animals during pregnancy and the developmental period are critically reviewed.

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Cited by 33 publications
(17 citation statements)
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“…For example, early rodent studies found that DEHP exposure was associated with decreased fetal and birth weight (31, 32]), while similar recent studies are consistent with our findings of no association (33, 34). Animal studies of in utero DBP exposure have also observed inconsistent effects on birth weight, with several studies reporting no effect (35-38), while others reported either decreased (39-41) or increased (42) birth weight.…”
Section: Discussionsupporting
confidence: 92%
“…For example, early rodent studies found that DEHP exposure was associated with decreased fetal and birth weight (31, 32]), while similar recent studies are consistent with our findings of no association (33, 34). Animal studies of in utero DBP exposure have also observed inconsistent effects on birth weight, with several studies reporting no effect (35-38), while others reported either decreased (39-41) or increased (42) birth weight.…”
Section: Discussionsupporting
confidence: 92%
“…Kaul et al (1982) reviewed the toxic effects of DEHP on the pregnant rodent and fetus. Developmental toxicity of DEHP includes reduced implantations, increased resorptions, decreased fetal body weight, and increased malformations.…”
Section: Reproductive and Developmental Toxicity In Animal Modelsmentioning
confidence: 99%
“…In women, chronic occupational exposure to phthalates is associated with an increased risk of miscarriage and a decreased rate of pregnancy [1]. In laboratory animals, DEHP causes pregnancy complications, including reduced implantations, increased resorptions, and decreased fetal weights of offspring [16, 17]. …”
Section: Introductionmentioning
confidence: 99%