A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Sawicki, Tomasz; Ruszkowska, Monika; Danielewicz, Anna; Niedźwiedzka, Ewa; Arłukowicz, Tomasz; Przybyłowicz, Katarzyna

doi:10.3390/cancers13092025

Cited by 439 publications

(352 citation statements)

References 140 publications

Supporting

Mentioning

247

Contrasting

Unclassified

Order By: Relevance

“…46 The risk of development of CRC due to a high-fat diet is thought to be due to exposure of gut mucosa to carcinogenic heterocyclic amines, polycyclic aromatic hydrocarbons, 47 and nitroso compounds. 48,49 Unlike the current study that did not find a strong relationship between diet and CRC, two previous studies demonstrated a significant relationship between plasma phospholipids and CRC. 50,51 As previously mentioned, poor documentation could have contributed to this negative finding.…”

Section: Dovepresscontrasting

confidence: 99%

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

Wekha

Ssewante

Iradukunda

et al. 2021

CMAR

View full text Add to dashboard Cite

Introduction:Colorectal cancer (CRC) is the most common type of gastrointestinal malignancies and the third leading cause of cancer-related deaths for both sexes worldwide. Although the burden of CRC is highest in developed countries, reports are indicating a rise in the incidence of early-onset CRC in developing countries. In this study, we aimed to determine the prevalence of CRC among patients hospitalized with lower gastrointestinal complaints at a tertiary health facility in Uganda. Methods: We conducted a 10-year retrospective chart review of patients admitted to Mulago National Referral Hospital in Kampala, Uganda, between 1st January 2010 and 31st December 2020. We reviewed all charts of patients admitted to the lower gastrointestinal tract (GIT) ward. Charts with grossly missing data, pediatric patients, and those from other non-lower GIT specialties were excluded. Results: Data of 1476 unique eligible patients were analyzed. Of these,138 had a diagnosis of CRC (prevalence: 9.3%, 95% confidence interval (95% CI): 6.5-11.7%). Among patients with CRC, the female:male ratio was 1:1. The most common site for CRC was the rectum (59.8%, n= 79). For the 138 participants with CRC, 44 had staging data with 72.8% (n=32) having advanced disease, that is, stage 3 or 4. Factors independently associated with CRC were age ≥50 years (adjusted odds ratio (aOR): 4.3, 95% CI: 2.6-7.1, p < 0.001), female sex (aOR: 1.8, 95% CI: 1.2 −2.8, p = 0.005), being widowed (aOR: 2.5, 95% CI: 1.3-5.0, p = 0.006), and presence of any risk factor for CRC (aOR: 5.3, 95% CI: 2.9-9.9, p < 0.001). Conclusion: CRC is relatively common among patients hospitalized with lower GIT complaints, particularly among women and those with known risk factors for CRC. Awareness creation and screening programs should be instituted to allow early diagnosis of CRC in our setting.

show abstract

Section: Dovepresscontrasting

confidence: 99%

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

Wekha

Ssewante

Iradukunda

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

“…Of course, a great many studies in the past few decades have identified novel prognostic biomarkers (39)(40)(41). Various studies have found that angiogenesis plays an important role in recurrence and metastasis (42,43).…”

Section: Discussionmentioning

confidence: 99%

The Chemokine CXCL7 Is Related to Angiogenesis and Associated With Poor Prognosis in Colorectal Cancer Patients

Jiang

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveThe present study was designed to investigate the role of the chemokine CXCL7 in angiogenesis and explore its prognostic value in colorectal cancer (CRC).MethodsA total of 160 CRC patients who had undergone surgery were included in this study, and staged according to the guidelines of the AJCC, 7th Edition. Expression of CXCL7 and VEGF was detected by immunohistochemical (IHC) staining and divided into high and low expression subgroups. The correlation between CXCL7 and VEGF expression was evaluated by Spearman’s rank-correlation coefficient. Prognosis based on CXCL7 and VEGF was evaluated using the Cox proportional hazards regression model and a nomogram of 5-year overall survival (OS) time.ResultsCXCL7 was highly expressed in tumor tissues (65.63% vs 25.00% in paracancerous tissue, P < 0.001), as was VEGF. CXCL7 and VEGF expression correlated well with N and TNM stage cancers (all P < 0.001). Importantly, CXCL7 was positively correlated with VEGF expression in CRC tissues. CXCL7 was an independent predictor of poor OS of CRC patients (HR = 2.216, 95% CI: 1.069-4.593, P = 0.032), and co-expression of CXCL7 and VEGF of predicted poor OS of 56.96 months.ConclusionExpression of CXCL7 correlated with VEGF and was associated with poor clinical outcomes in CRC patients.

show abstract

“…Nowadays, the role of noncoding RNAs such as miRNAs, long non-coding RNAs, and circular RNAs has been recognized in the pathogenesis of different diseases including cancer [ 26 ]. CRC is one of the most frequent neoplasms in the world and 1.9 million new CRC patients were diagnosed in 2020 [ 27 ]. So far, the involvement of a number of circular RNAs including ciRS-7-A [ 28 ], circITGA7 [ 29 ], PIP5K1A [ 30 ], GLIS2 [ 31 ], and HIPK3 [ 32 ] in the development of colorectal cancer has been identified.…”

Section: Discussionmentioning

confidence: 99%

Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1

et al. 2021

View full text Add to dashboard Cite

Introduction Colorectal cancer (CRC) is one of the most frequent neoplasms in the world. Based on the emerging role of noncoding RNAs, particularly circular RNAs in pathogenesis of cancers, we designed this study to inspect the expression levels of a circ0009910-mediated regulatory pathway in colorectal cancer. Methods After bioinformatics analyses and construction of putative circ0009910/ miR-145-5p/PEAK1 pathway, the expression levels of these components were evaluated in 50 CRC tissues and adjacent specimens by quantitative real-time PCR. Moreover, we appraised the correlation coefficients between these transcripts and calculated the correlation between circ0009910 expression levels with clinicopathological features of patients. Results Circ0009910 and PEAK1 were significantly upregulated, while miR-145-5p was decreased in CRC samples compared with adjacent tissues (p < 0.05). Moreover, statistically significant correlations were observed between expression levels of circ0009910, miR-145-5p, and PEAK1. We also reported considerable correlations between circ0009910 expression and clinicopathological parameters including sex and perineural invasion. Finally, ROC curve analysis showed circ0009910 level as a discriminative biomarker for CRC. Conclusion For the first time, we could introduce circ0009910 as an important biomarker in CRC. Collectively, this investigation helped us to identify a newly diagnosed pathway in CRC that can be a potential axis for designing effective drugs for treatment of CRC patients.

show abstract

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Cited by 439 publications

References 140 publications

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

The Chemokine CXCL7 Is Related to Angiogenesis and Associated With Poor Prognosis in Colorectal Cancer Patients

Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1

Contact Info

Product

Resources

About