A Review of Adult-Onset Hearing Loss: a Primer for Neurologists

Pittman, Corinne A.; Ward, Bryan K.; Nieman, Carrie L.

doi:10.1007/s11940-021-00674-4

Cited by 6 publications

(2 citation statements)

References 87 publications

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“…In addition to the pure prognosis in terms of hearing rehabilitation, especially in elderly patients, the proven positive impact on cognitive function should also be considered [ 32 , 33 ]. Since hearing loss represents an independent and treatable risk factor for the development of dementia, this should be discussed in detail during patient counseling and evaluated as a therapeutic rationale in light of the limited prognosis.…”

Section: Discussionmentioning

confidence: 99%

Hearing rehabilitation for unilateral deafness using a cochlear implant: the influence of the subjective duration of deafness on speech intelligibility

Waleka

Strieth

Eichhorn³

et al. 2022

Eur Arch Otorhinolaryngol

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Background For patients with single sided deafness (SSD) or severe asymmetric sensorineural hearing loss (ASHL), cochlear implantation remains the only solution to restore bilateral hearing capacity. Prognostically, the duration of hearing loss in terms of audiological outcome is not yet clear. Therefore, the aim of this study was to retrospectively investigate the influence of subjective deafness duration on postoperative speech perception after cochlear implantation for SSD as well as its impact on quality of life. Materials and methods The present study included a total of 36 adults aged 50.2 ± 15.5 years who underwent CI for SSD/ASHL at our clinic between 2010 and 2015. Patients were audiometrically assessed at 3 and 12–36 months postoperatively. Test results were correlated with self-reported duration of deafness. Quality of life was assessed by questionnaire. Results Mean duration of deafness was 193.9 ± 185.7 months. The side-separated hearing threshold showed an averaged target range between 30 and 40 dB HL. Freiburg monosyllable test increased from 0% pre-operatively to 20% after 3 months (p = 0.001) and to 50% after 12–36 months (p = 0.002). There was a significant correlation between audiometric outcome and subjective deafness duration at 12–36 months postoperatively (r = − 0.564; p = 0.02) with a cutoff for open-set monosyllable recognition at a duration of deafness of greater than 408 months. Quality of life was significantly improved by CI. Conclusions CI implantation in unilaterally deafened patients provides objective and subjective benefits. Duration of deafness is unlikely to be an independent negative predictive factor and thus should not generally be considered as contraindication.

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Section: Discussionmentioning

confidence: 99%

Hearing rehabilitation for unilateral deafness using a cochlear implant: the influence of the subjective duration of deafness on speech intelligibility

Waleka

Strieth

Eichhorn³

et al. 2022

Eur Arch Otorhinolaryngol

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“…Hearing loss affects one out of six people and it is one of the major common sensory impairments of humans worldwide [656,671,672]. Hearing loss can be caused by various extrinsic and intrinsic factors, i.e., noise exposure, drug application (including cisplatin), infections and age-related degeneration [672][673][674][675]. The hearing loss in general results from compromised functioning of the organ of Corti in the cochlea and/or the nerve pathways connected to the auditory part of the brain [676].…”

Section: Role Of Nox3 In Hearing Lossmentioning

confidence: 99%

NADPH Oxidase 3: Beyond the Inner Ear

Herb

2024

Antioxidants

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Reactive oxygen species (ROS) were formerly known as mere byproducts of metabolism with damaging effects on cellular structures. The discovery and description of NADPH oxidases (Nox) as a whole enzyme family that only produce this harmful group of molecules was surprising. After intensive research, seven Nox isoforms were discovered, described and extensively studied. Among them, the NADPH oxidase 3 is the perhaps most underrated Nox isoform, since it was firstly discovered in the inner ear. This stigma of Nox3 as “being only expressed in the inner ear” was also used by me several times. Therefore, the question arose whether this sentence is still valid or even usable. To this end, this review solely focuses on Nox3 and summarizes its discovery, the structural components, the activating and regulating factors, the expression in cells, tissues and organs, as well as the beneficial and detrimental effects of Nox3-mediated ROS production on body functions. Furthermore, the involvement of Nox3-derived ROS in diseases progression and, accordingly, as a potential target for disease treatment, will be discussed.

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Vestibular Disorders

Gold

2021

Neuro-Ophthalmology and Neuro-Otology

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A Review of Adult-Onset Hearing Loss: a Primer for Neurologists

Cited by 6 publications

References 87 publications

Hearing rehabilitation for unilateral deafness using a cochlear implant: the influence of the subjective duration of deafness on speech intelligibility

Hearing rehabilitation for unilateral deafness using a cochlear implant: the influence of the subjective duration of deafness on speech intelligibility

NADPH Oxidase 3: Beyond the Inner Ear

Vestibular Disorders

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