A review of 14 cases of hypertrophic osteopathy (Marie's disease) in horses in the Republic of Ireland

Enright, Katherine; Tobin, Emma; Katz, Lisa

doi:10.1111/j.2042-3292.2010.00139.x

Cited by 11 publications

(15 citation statements)

References 13 publications

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“…The diagnosis of HO (Marie's disease) was made from the clinical signs, radiographic features of the long bones, presence of a large intra‐abdominal mass concurrently and response to treatment. Hypertrophic osteopathy is a poorly understood, rare condition characterised by symmetrical proliferation of connective tissue and subperiosteal bone along the diaphysis of the long bones (Mair and Tucker 2004; Enright et al . 2011).…”

Section: Discussionmentioning

confidence: 99%

“…2009) and macropods (Wayne and Nicholson 1999). In the human literature, the condition is referred to as hypertrophic osteoarthropathy (HOA) due to associated arthritis (Nguyen and Hojjati 2011); however, in animal species direct association with the joints does not appear to occur (Enright et al . 2011).…”

Section: Discussionmentioning

confidence: 99%

“…1998). In the horse, HO is a rare condition (Mair and Tucker 2004), characterised by the symmetrical proliferation of connective tissue and subperiosteal new bone formation along the diaphyses of the limb bones, although the mandible and maxilla can also be affected in more severe cases (Enright et al . 2011).…”

Section: Introductionmentioning

confidence: 99%

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Granulosa thecal cell tumour in a mare causing hypertrophic osteopathy

Packer

McKANE²

2011

Equine Veterinary Education

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Summary Hypertrophic osteopathy (HO) is a rare condition in the horse characterised by symmetrical proliferation of connective tissue and subperiosteal bone, along the diaphyses of limb bones. In this case, a 10‐year‐old Irish Draught cross Thoroughbred mare was presented for investigation of weight loss, lethargy and firm swelling of all 4 distal limbs. Radiographs of the distal limbs revealed palisade‐like periosteal new bone formation perpendicular to the cortex of the distal third metacarpal and metatarsal bones, proximal (P1) and mid (P2) phalanges. Rectal examination revealed a mass of approximately 20 x 30 cm in the right caudoventral abdomen. The mare was diagnosed with HO due to a granulosa thecal cell (GTC) tumour. The GTC tumour was removed and the diagnosis confirmed on histological examination. Clinical examination and radiographs of the distal limbs after surgery demonstrated reduction in size of the limb swellings and new bone formation. To the authors' knowledge this is the first report of HO due to a GTC tumour in a mare.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Granulosa thecal cell tumour in a mare causing hypertrophic osteopathy

Packer

McKANE²

2011

Equine Veterinary Education

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“…A última denominação é usada para designar a doença em humanos devido ao frequente envolvimento articular, o que não ocorre nos cães, nos quais a lesão se concentra nos ossos (Goldstraw & Walbaum 1976, Liptak et al 2004. Além de humanos e cães, espécies nas quais a doença ocorre com maior frequência, OH também tem sido descrita em gatos (Grierson et al 2003, Johnson & Lenz 2011, equinos (Mair et al 1996, Heinola et al 2001, Enright et al 2011, bovinos (Martin et al 1971), veados (Ferguson et al 2008), visons (Wilton & Graesser 1967), primatas e leões (Brodey 1971).…”

Section: Introductionunclassified

Osteopatia hipertrófica em sete cães

et al. 2012

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Pesq. Vet. Bras. 32(5): 424-429, maio 2012 424 RESUMO.-Os achados clínico-patológicos de sete casos de osteopatia hipertróϐica em cães foram estudados. Os cães afetados apresentavam sinais clínicos indicativos de envolvimento ósseo e lesões macroscópicas principalmente nos ossos longos dos membros. As lesões consistiram de neoformação óssea periosteal detectada em exame radiográ-ϐico, na inspeção óssea durante a necropsia e, com grande nível de detalhamento, em espécimes ósseos macerados. A proliferação óssea observada era parcialmente circunferencial e ocorreu principalmente na diáϐise dos ossos longos. Era constituída por trabéculas ósseas de tamanho e espessura irregulares que estavam dispostas de forma perpendicular ao córtex ósseo original. Em todos os casos as lesões de osteopatia hipertróϐica foram associadas a neoplasmas pulmonares (primários ou metastáticos). Clinical and pathological aspects of hypertrophic osteopathy in seven dogs were studied. Affected dogs had clinical signs of bone involvement and lesions mainly in the long bones of the limbs. The lesions consisted of periosteal new bone formation detected on radiographic examination, inspection of bones during the necropsy, and with great detail, in macerated bone specimens. The bone proliferation observed was partially circumferential and occurred mainly in the diaphysis of long bones. It consisted of bone trabeculae of irregular size and thickness that were arranged perpendicularly to the original bone cortex. In all cases the lesions were associated with lung neoplasms (primary or metastatic).INDEX TERMS: Diseases of dogs, bone pathology, periosteal proliferation, hypertrophic osteopathy, Marie's disease.

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“…Chaffin et al (1990) reported HO regression after treatment of an intrathoracic abscess in a horse. Enright et al (2011) described HO regression in two animals treated with nonsteroidal antiinflammatories (NSAIDs) and corticosteroids. The horses had HO secondary to splenomegaly and inflammatory airway disease, respectively.…”

Section: Case Reportmentioning

confidence: 99%

Hypertrophic osteopathy associated with systemic granulomatous disease in a horse

et al. 2016

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A 4-year-old Criollo stallion was presented at the equine clinic of veterinary hospital of the Federal University of Santa Maria, RS, with a 30-day history of progressive weight loss, anemia and swelling of the forelimbs and face. Physical examination revealed that the swelling was firm and had a bone-like consistency, also radiographs showed extensive periosteal proliferation on the forelimb long bones that suggested hypertrophic osteopathy (Marie´s disease). Physical examinations identified no respiratory findings. However, during ultrasound examination, superficial lung disease was identified. The animal was treated with antibiotics and nonsteroidal anti-inflammatory drugs for 12 days. Due to a complete lack of response to this treatment, the horse was euthanized. At necropsy several granulomatous lesions were identified in the thorax, abdomen and testicular tunics. Bony proliferation was evident on many bones of the appendicular skeleton and face. Based on these findings the diagnosis of hypertrophic osteopathy associated with sarcoidosis was established. It is important to perform a thorough clinical examination and include hypertrophic osteopathy in the differential diagnosis of diseases that are accompanied by swelling of the face and limbs as edema from various causes, fibrous osteodystrophy, for example. aumento de volume era firme e apresentava consistência óssea. Radiografias também mostraram extensa proliferação periosteal nos ossos longos dos membros anteriores, o que sugeriu a osteopatia hipertrófica (doença de Marie). Os exames físicos não identificaram alteração respiratória. No entanto, durante o exame ultrassonográfico, foi identificada doença pulmonar superficial. O animal foi tratado com antibióticos e anti-inflamatórios não esteróides durante 12 dias. Devido a uma completa falta de resposta ao tratamento, o cavalo foi sacrificado. Durante a necropsia, várias lesões granulomatosas foram identificadas no tórax, abdômen e túnicas testiculares. Proliferação óssea era evidente em vários ossos do esqueleto apendicular e da face. Com base nestes resultados o diagnóstico de osteopatia hipertrófica associada à sarcoidose foi estabelecido. É importante realizar um exame clínico completo e incluir a osteopatia hipertrófica no diagnóstico diferencial de enfermidades que vêm acompanhadas de aumento de volume da face e dos membros como edema por diversas causas e osteodistrofia fibrosa, por exemplo. Palavras-chave: Pulmonar. Periósteo. Sarcoidose. Patologia.

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A review of 14 cases of hypertrophic osteopathy (Marie's disease) in horses in the Republic of Ireland

Cited by 11 publications

References 13 publications

Granulosa thecal cell tumour in a mare causing hypertrophic osteopathy

Granulosa thecal cell tumour in a mare causing hypertrophic osteopathy

Osteopatia hipertrófica em sete cães

Hypertrophic osteopathy associated with systemic granulomatous disease in a horse

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