A retrospective study evaluating the association between hypoalbuminemia and postoperative outcomes for patients receiving open rotator cuff repair

Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism

“…For repair of open rotator cuffs, Quan et al describe that HA patients faced a fourfold increase in odds for hospital readmissions. 29 Similar findings are reported by Sloan et al who found that following primary total knee arthroplasty, patients with preoperative albumin values of less than 3.5 g/dL exhibited increased odds of readmission. 38 This association has been seen in other otolaryngological procedures as well.…”

“…A similar finding by Moghadamyeghaneh et al identified HA colorectal surgery patients were nearly two times more likely to experience hospitalization for more than 30 days compared with non‐HA counterparts 28 . Quan et al reported similar findings in which HA patients undergoing open repair of the rotator cuff faced an increased risk of extended hospital care 29 . Because serum albumin can serve as a proxy for nutrition status, low levels can effectively represent malnutrition 30 .…”

“…28 Quan et al reported similar findings in which HA patients undergoing open repair of the rotator cuff faced an increased risk of extended hospital care. 29 Because serum albumin can serve as a proxy for nutrition status, low levels can effectively represent malnutrition. 30 In the literature, malnutrition has been associated with susceptibility to illness and issues with healing, which may explain the relationship between HA and prolonged LOS following surgical treatment.…”

“…In this analysis, HA was defined as serum albumin of less than 3.5 g/dL. To analyze differences between the non-HA and HA cohorts and to adjust for confounding factors, the following patient demographics and comorbidities provided by NSQIP were included in the analysis: sex (male, female), age (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49), 50-64, 65+ years), race (White, Black, Asian, Hawaiian/Pacific, and Native American), Hispanic ethnicity (Hispanic and non-Hispanic), obesity, diabetes, smoker, dyspnea, poor functional status, ventilator dependence, chronic obstructive pulmonary disease (COPD), ascites, congestive heart failure (CHF), hypertension, renal failure, dialysis, disseminated cancer, open wounds, steroid use, weight loss, bleeding disorders, preoperative blood transfusions, and systemic sepsis.…”

The Role of Perioperative Nutritional Status and Supplementation in Orthopaedic Surgery

“…These physiologic stress events cause a surge in oxidative stress and inflammation, increased metabolic demands to facilitate tissue repair, and a balance of protein synthesis and catabolism to maintain gluconeogenesis 21 . Although essential for proper recovery, this delicate balance can be tipped in favor of catabolism as metabolic reserves are depleted, leading to impaired immunity, disrupted healing, increased hospital length of stay (LOS), sepsis, mortality, and other clinically meaningful negative outcomes across all orthopaedic subspecialties 13,22-27 . This process is compounded by reduced oral intake, with an estimated 50% to 91.5% of orthopaedic patients reporting suboptimal intake in the perioperative period 28-31 .…”