A resting-state fMRI study of patients with HIV infection based on regional homogeneity method

Qiu, Wenjuan; Yan, Bin; Li, Jianxin; Li, Tong; Shi, Dapeng

doi:10.1109/icnc.2011.6022180

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Structural MRI has frequently shown that reduced subcortical volumes in HIV-infected individuals are related to neurocognitive impairment (Dal Pan et al 1992; Aylward et al 1993; Paul et al 2002; Ances et al 2006). The findings reported by Qui et al (2011) support our results. Specifically, Qui et al (2011) reported reduced regional homogeneity in the thalamus.…”

Section: Discussionsupporting

confidence: 92%

“…The findings reported by Qui et al (2011) support our results. Specifically, Qui et al (2011) reported reduced regional homogeneity in the thalamus. Again, thalamic involvement may reflect a sub-cortical pattern commonly seen in untreated HIV.…”

Section: Discussionsupporting

confidence: 92%

“…HIV-B infected individuals exhibit altered connectivity in the attention network (Ortega et al 2015), thalamus (Qui et al 2011), and the default mode network (DMN) (Thomas et al 2013; Wang et al 2011), when compared to HIV− controls. Only Wang et al (2011) identified a link between connectivity and cognitive performance in HIV-B where connectivity in the lateral occipital cortex network was correlated with a task involving visual-motor coordination.…”

Section: Introductionmentioning

confidence: 99%

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Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function

et al. 2017

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Neuroimaging abnormalities are common in chronically infected HIV-positive individuals. The majority of studies have focused on structural or functional brain outcomes in samples infected with clade B HIV. While preliminary work reveals a similar structural imaging phenotype in patients infected with clade C HIV, no study has examined functional connectivity (FC) using resting state functional magnetic resonance imaging (rs-fMRI) in clade C HIV. In particular, we were interested to explore HIV-only effects on neurocognitive function using associations with rs-fMRI. In the present study, 56 treatment-naïve, clade C HIV-infected participants (age 32.27 ± 5.53 years, education 10.02 ± 1.72 years, 46 female) underwent rs-fMRI and cognitive testing. Individual resting state networks were correlated with Global Deficit Scores (GDS) in order to explore associations between them within an HIV-positive sample. Results revealed 10 regions in 6 resting state networks where FC inversely correlated with GDS scores (worse performance). The networks affected included three independent attention networks, the default mode network (DMN), sensorimotor network, and basal ganglia. Connectivity in these regions did not correlate with plasma viral load or CD4 cell count. The design of this study is unique and has not been previously reported in clade B. The abnormalities related to neurocognitive performance reported in this study of clade C may reflect late disease stage and/or unique host/viral dynamics. Longitudinal studies will help to clarify the clinical significance of resting state alterations in clade C HIV.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function

et al. 2017

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Review of functional MRI in HIV: effects of aging and medication

et al. 2016

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HIV-associated neurocognitive disorder (HAND) is a frequently occurring comorbidity of HIV infection. Evidence suggests this condition starts subclinical before a progression to a symptomatic stage. Blood oxygenated level dependent (BOLD) fMRI has shown to be a sensitive tool to detect abnormal brain function in an early stage and might therefore be useful to evaluate the effect of HIV infection on brain function. An extensive literature search was performed in June 2015. Eligibility criteria for included studies were as follows: (1) conducting with HIV-positive patients, (2) using BOLD fMRI, and (3) including a HIV-negative control group. A total of 19 studies were included in the review including 931 participants. Differences in activation between HIV-positive and -negative participants were found when testing multiple domains, i.e., attention, (working) memory, and especially executive functioning. Overall, HIV-positive patients showed hyperactivation in task-related brain regions despite equal performances as controls. Task performance was degraded only for the most complex tasks. A few studies investigated the effect of aging on fMRI, and most of them found no interaction with HIV infection. Only three studies evaluated the effect of combination antiretroviral therapy (cART) on functional data suggesting an increase in activation with the use of cART. fMRI is a sensitive instrument to detect subtle cognitive changes in HIV patients. Open questions remain regarding the effects of cART on fMRI and the effects of aging on fMRI.Electronic supplementary materialThe online version of this article (doi:10.1007/s13365-016-0483-y) contains supplementary material, which is available to authorized users.

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The Individualized Prediction of Neurocognitive Function in People Living with HIV Based on Clinical and Multimodal Connectome Data

Towe

Bell

et al. 2023

IEEE J. Biomed. Health Inform.

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A resting-state fMRI study of patients with HIV infection based on regional homogeneity method

Cited by 3 publications

References 23 publications

Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function

Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function

Review of functional MRI in HIV: effects of aging and medication

The Individualized Prediction of Neurocognitive Function in People Living with HIV Based on Clinical and Multimodal Connectome Data

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