A Resampling Univariate Analysis Approach to Ovarian Cancer From Clinical and Genetic Data

Abstract

Ovarian cancer (OC) is the second most common gynecological malignancy and the gynecological tumor with the worst prognosis. To try to improve this situation, Data Science technologies could be a useful tool to help clinicians to know more about the disease. In our case, we are interested in exploring OC data to discover relationships between clinical and genetic factors and the disease progression. For it, we propose an analysis framework for simple and univariate statistical descriptions of features of different types, based on bootstrap resampling. Foremost, we define the framework for metric, categorical, and dates variables and determine what are the advantages and disadvantages of using different bootstrap resampling strategies, based on their statistical basis. Then, we use it to perform a univariate analysis over an OC dataset that allows to explore how is the disease progression, having platinum-free interval as indicator, in relation to clinical and genetic features of different types. Also, it provides a first set of variables possibly relevant for survival prediction. Results obtained show that some features have led to individual differences between both platinum resistant (<6 months) and platinum sensitive(>6 months) groups. It can be concluded that this could be an indicator that the database could be discriminatory for the hypotheses studied, though it is convenient to make multivariate analyses to check how relationships among features are influenced.

Adversarial selective domain adaptation with feature cluster for skin cancer diagnosis

“…Dermoscopy is commonly used as a noninvasive skin imaging method for the detection of melanoma. Without any additional observation, the accuracy for identifying melanoma is higher by utilizing dermoscopy [5]. However, the diagnostic accuracy depends on the dermatologist's professional and experience skills.…”

ACO-KELM: Anti Coronavirus Optimized Kernel-based Softplus Extreme Learning Machine for classification of skin cancer

“…Recently, the growth of deep learning (DL) in the field of machine learning has greatly enhanced the performance of medical imaging. Several studies have shown the efficacy of classification-based DL, also known as image-based ML, which uses images as its primary input ( Bote-Curiel et al, 2021 , Chaki and Woźniak, 2023 , Chiu et al, 2022 , Dhini et al, 2022 , Saba et al, 2019 ).…”