1993
|
|

Abstract: Congeners of nitrogen monoxide (NO) are neuroprotective and neurodestructive. To address this apparent paradox, we considered the effects on neurons of compounds characterized by alternative redox states of NO: nitric oxide (NO.) and nitrosonium ion (NO+). Nitric oxide, generated from NO. donors or synthesized endogenously after NMDA (N-methyl-D-aspartate) receptor activation, can lead to neurotoxicity. Here, we report that NO.- mediated neurotoxicity is engendered, at least in part, by reaction with superoxid… Show more

Help me understand this page

Search citation statements

Order By: Relevance
0
0
0
0
0
32
1,236
2
11

Publication Types

Select...

Relationship

0
0

Authors

Journals