A Rare Etiology of Abnormally Large Gastric Folds: Menetrier’s Disease

Kamal, Muhammad Umar; Tariq, Hassan; Mehak, Vaniza; Azam, Sara; Kumar, Kishore; Niazi, Masooma; Dev, Anil

doi:10.1155/2019/7927083

Cited by 5 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Upper gastrointestinal bleeding has been reported as a rare manifestation of Ménétrier’s disease. The bleeding may present as hematemesis or, like in this case, as melena[ 10 , 11 ]. One patient developed deep vein thrombosis and received anticoagulation therapy, which led to gastrointestinal bleeding[ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Kmiecik¹,

Walczak²,

Samborski³

et al. 2023

World J Gastrointest Endosc

View full text Add to dashboard Cite

BACKGROUND Ménétrier’s disease is a rare condition characterized by enlarged gastric folds, usually located in the whole body and fundus of the stomach. This report presents an unusual case of localized Ménétrier’s disease elevated by a submucosal lipoma and thus looking like a polypoid mass and causing an episode of upper gastrointestinal bleeding. The mass was successfully removed with endoscopic submucosal dissection. CASE SUMMARY Esophagogastroduodenoscopy was performed on a 76-year-old male patient after an episode of upper gastrointestinal bleeding, manifesting as fatigue and melena. A large polypoid mass (4 cm × 1 cm) with enlarged mucosal folds was found in the body of the stomach, between the lesser curvature and posterior wall. A small ulcer at the distal end of the mass was identified as the source of the bleeding. Biopsy was negative for neoplasia. Computed tomography showed a submucosal lesion beneath the affected mucosa, most likely a lipoma. The mass was removed en bloc with tunneling endoscopic submucosal dissection. Final pathology determined that the mass included Ménétrier’s disease and a submucosal lipoma. The patient was scheduled for follow-up esophagogastroduodenoscopy. CONCLUSION Localized Ménétrier’s disease can coexist with a submucosal lipoma creating a polypoid mass with risk of bleeding.

show abstract

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Kmiecik¹,

Walczak²,

Samborski³

et al. 2023

World J Gastrointest Endosc

View full text Add to dashboard Cite

show abstract

“…One study reported that H. pylori was present in 90% of Menetrier cases [ 4 ]. There is also a strong correlation with the overexpression of transforming growth factor-alpha (TGF-a), an epidermal growth factor receptor (EGFR) that is thought to play a major role in the proliferation of the gastric epithelium and gastric mucosal cells [ 5 ]. It is theorized that H. pylori plays a role in this overexpression.…”

Section: Discussionmentioning

confidence: 99%

“…The protein loss, specifically albumin, causes a state of fluid extravasation in peripheral tissues, leading to edema, most prominent in the lower extremities. Patients can also present with gastrointestinal bleeding [ 5 ]. There have been few reports of Menetrier presenting with intussusception, causing small bowel obstruction [ 1 , 2 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiological Features of Menetrier’s Disease: A Case Report and Review of the Literature

Keener,

Waack,

Ranabothu

et al. 2023

Cureus

View full text Add to dashboard Cite

We present a case report describing the diagnosis and management of a patient who presents with a rare diagnosis of Menetrier’s disease. This condition poses a diagnostic challenge to clinicians due to its nonspecific clinical presentation and is oftentimes misdiagnosed for more common gastric disorders. Menetrier’s disease is characterized by gastric mucosal hypertrophy and subsequent protein loss, resulting in gastric symptoms and widespread edema. While the etiology remains unclear, notable associations have been observed with Helicobacter pylori ( H. pylori ) infection and overexpression of transforming growth factor-alpha (TGF-a). The management often involves supportive measures with medical and surgical interventions for refractory cases and when necessary. This report includes a comprehensive review of the literature on the clinical presentation, diagnostic approach, and management of this rare disease. By documenting such cases in the medical literature, we aim to enhance the clinician’s ability to recognize and manage this disorder, thereby preventing the development of more severe manifestations such as gastric carcinoma.

show abstract

“…Therefore, he believed that the disease involved the stomach and the fundus of the stomach, and the antrum was preserved. The disease has a certain connection with gastric cancer[ 4 , 5 ]. With the continuous reports of cases, we have found that a few cases can involve the gastric antrum.…”

Section: Introductionmentioning

confidence: 99%

Menetrier’s disease and differential diagnosis: A case report

Wang¹,

Zhao²,

Wang³

et al. 2021

WJCC

View full text Add to dashboard Cite

BACKGROUND Gastric mucosal hypertrophy, also known as Menetrier's disease (MD), is more common in men over 50 years of age, and the cause is unknown. The symptoms of the disease are atypical, mostly accompanied by hypoproteinemia and edema, and sometimes accompanied by symptoms such as epigastric pain, weight loss, and diarrhea. Most experts believe that the site of the disease is mainly located in the fundus of the stomach and the body of the stomach. We found that the site of the disease in this patient involved the antrum of the stomach. CASE SUMMARY We introduced the case of a 24-year-old woman who had repeated vomiting for 5 d and was admitted to our hospital. After various examinations such as computed tomography and pathology in our hospital, the final diagnosis of the presented case is MD. The salient feature is that the mucosal folds in the fundus and body of the stomach are huge and present in the shape of gyrus. The greater curvature is more prominent, and there are multiple erosions or ulcers on the folds. The patient did not undergo gastric surgery and did not undergo re-examination. She is drinking Chinese medicine for treatment, and her vomiting and abdominal pain symptoms have improved. This disease is relatively rare in clinical practice, and it is easy to be misdiagnosed as gastric cancer, chronic gastritis and gastric lymphoma, etc . CONCLUSION MD can occur in the antrum, it is necessary to raise awareness of the disease and reduce misdiagnosis.

show abstract

A Rare Etiology of Abnormally Large Gastric Folds: Menetrier’s Disease

Cited by 5 publications

References 23 publications

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Upper gastrointestinal bleeding as an unusual manifestation of localized Ménétrier’s disease with an underlying lipoma: A case report

Clinical and Radiological Features of Menetrier’s Disease: A Case Report and Review of the Literature

Menetrier’s disease and differential diagnosis: A case report

Contact Info

Product

Resources

About