A rare coexistence of a multicentric hepatic hemangioendothelioma with a large brain hemangioma in a preterm infant

Abstract

A preterm infant with a rare association of a multicentric hepatic hemangioendothelioma (MHH) and a large brain hemangioma is described. The imaging investigations and their findings are discussed. It is recommended that whole-body radionuclide imaging with 99mTc-labeled red blood cells is employed immediately following ultrasonography to confirm the suspected diagnosis of MHH and to detect other unsuspected hemangiomas.

Infantile Hemangiomas Involving the Neuraxis: Clinical and Imaging Findings

“…9 Other associated findings reported included cerebellar hypoplasia and atrophy, persistent trigeminal artery, periventricular gray matter heterotopia, cerebral AVM in 1 patient, Dandy-Walker complex, and multifocal hepatic hemangiomas. [3][4][5]8,24 Reported examples of intraspinal hemangiomas are even rarer, numbering 5.…”

Hemangioma of the liver in children: Proliferating vascular tumor or congenital vascular malformation?

“…They are usually present in infants less than 6 months of age [1], and are frequently associated with high output cardiac failure due to arteriovenous shunts located within the tumor. HVT have been reported to be associated with anemia [2], consumptive coagulopathy [3], Kasabach-Merritt syndrome [4], tumor rupture and hemorrhage [5], jaundice [6], and hemangiomas of skin and other organs [7][8][9]. Histologically, HVT are derived from mesenchymal tissue elements and are classified as hemangioendothelioma (HE) or cavernous hemangioma (HC; [10,11]).…”

Association of Solitary, Segmental Hemangiomas of the Skin With Visceral Hemangiomatosis

“…The liver was the most common extracu- taneous site, followed by the gastrointestinal tract, brain, mediastinum, and lung. Of the patients in whom laterality of both the visceral and cutaneous hemangiomas were noted, 7 had ipsilateral facial and intracranial hemangiomas 4,6,14,22 ; only 1 was contralateral. 22 Two cases each of pulmonary 6,8 and liver hemangiomatosis 4,6 were also noted to be ipsilateral to their cutaneous hemangioma.…”