A Rare Case of Renal Cell Carcinoma Metastasis in the Parotid Gland Eleven Years After the Initial Diagnosis

Hosn-Centenero, Samir Aboul; Coll-Anglada, Manel; Pradillos-Garcés, Alba; Salinas-Duffo, David

doi:10.1016/j.otoeng.2014.10.006

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Our research strategy revealed a total of 83 relevant papers published from 1965-2022 (a few references). [ 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 ] A total of 100 patients included 55 males and 35 females with a male to female ratio of 1.6:1. The maximum number of cases were from the USA ( n = 17) followed by Poland ( n = 11), Turkey = UK ( n = 10), and Japan = Italy ( n = 8).…”

Section: Resultsmentioning

confidence: 99%

Renal cell carcinoma metastasizing to salivary glands: Systematic review

Gupta,

Alruwaili,

Escobedo

et al. 2024

National Journal of Maxillofacial Surgery

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Distant metastasis to salivary glands is a very rare event. Renal cell carcinoma (RCC) has been known for its high propensity of metastasis to unusual locations and salivary glands are one among those sites. Approximately 0.1% of all salivary gland metastatic neoplasms originate from renal malignancies Literature has reported several studies analysing the metastatic tumors to the oral region. However, very little research work has been published to date to analyse solely the RCC metastasizing to the salivary glands. Thus, this review was conducted to examine the published cases of RCC metastasizing to salivary glands in the literature to date and to learn about their characteristics. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (‘Renal cancer’, OR ‘Renal carcinoma’ OR ‘Renal cell cancer’ OR ‘Renal cell carcinoma’), AND (‘Metastasis’ OR ‘Metastases’), And (‘Salivary glands’ OR ‘Parotid gland’ OR ‘Submandibular gland’ OR ‘Sublingual gland’). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed a total of 83 relevant papers (1965-2022) with 100 patients. Parotid was the most predominant gland affected. 8% of patients died with a mean survival time of 1.3 yr. From this research, it can be concluded that RCC metastasizing to salivary glands is a rare occurrence. Careful evaluation of these cases is needed in order to raise awareness of these lesions and gain a better understanding of their characteristics for clinical as well as global implications.

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Section: Resultsmentioning

confidence: 99%

Renal cell carcinoma metastasizing to salivary glands: Systematic review

Gupta,

Alruwaili,

Escobedo

et al. 2024

National Journal of Maxillofacial Surgery

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“…The first cases of parotid involvement due to RCC metastases were reported by Patey et al in 1965 7 . Since then, there have been limited reported cases of this phenomenon 6,[8][9][10][11][12][13][14][15][16] . In their review of the literature, Lawlor et al reported 45 cases of RCC metastasizing to the parotid, of which only 31 were complete case presentations 6 .…”

Section: Discussionmentioning

confidence: 99%

Rare case of Clear Cell Renal Cell Carcinoma metastasizing to contralateral kidney and ipsilateral parotid more than five years following nephrectomy

Sydney¹,

Ioakim²,

Kara³

et al. 2019

Balkan J Dent Med

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Summary Backgroung/Aim: Salivary gland malignancies are rare, with only a fraction due to metastases. We report a rare case of the Clear Cell Renal Cell Carcinoma (CCRCC), a subtype of the Renal Cell Carcinoma (RCC), metastasizing to the parotid gland more than five years following nephrectomy. Case report: A 75-year-old female presented with a unilateral left parotid mass that was growing over the period of 18 months. After clinical and laboratory examinations, the patient underwent left partial superficial parotidectomy with preservation of the facial nerve. The significance of the patient’s history of the CCRCC was pivotal to the histopathological diagnosis of a metastatic CCRCC to the parotid. Conclusions: The unpredictable nature of the RCC results in the need for a long period of follow-up, as well as having a high degree of suspicion of metastasis in a patient presenting with a medical history of the RCC and a parotid mass.

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“…15,[33][34][35][36][37] Within the head and neck, metastases of RCC to the parotid are even less common, with approximately 28 reported cases thus far in the literature. [7][8][9][10][11][12][13][14][15][16][17][19][20][21][22][38][39][40] At rare occasions, metastatic disease has been the initial presenting symptom and the reason the primary tumor was identified. 8,18,22,41 In all reported cases of metastatic RCC to the parotid gland, the most common presenting symptom was a painless mass with or without facial paralysis and, less often, neurosensory disturbances.…”

Section: Discussionmentioning

confidence: 99%

“…Involvement of the parotid has been reported most commonly along with widely spread disease, whereas only 28 cases of solitary involvement have been reported thus far. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Most of these cases are late presentations, several years after treatment of the primary tumor. In contrast, brain metastases from RCC are reported early in the course of the disease process, within the first 1 to 2 years, with an incidence up to 17%.…”

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confidence: 99%