A rare case of plexiform schwannoma of the lower lip: Treatment and management

Abstract

An 18-year-old female presented with a swelling on the lower lip, which was insidious in onset and gradually progressive. The mass was completely excised under local anaesthesia. Complete histopathologic and immunohistochemical studies were conducted. The Antoni A areas were found along with typical verocay bodies composed of palisading nuclei and surrounding spaces filled with eosinophilic filaments. No necrosis was noted and there were no atypical mitotic figures. In the Antoni B region, a closely textured matrix with areas of edema, myxomatous changes, cystic degeneration and dilated vessels were noted. On the basis of the histopathologic and immunohistochemical staining with S-100 protein, a diagnosis of plexiform schwannoma was made and has been reported in this study. The post-operative view confirmed complete recovery after 6 weeks of surgery. This is a rare case with the tumour located in the lower lip, as very few cases have been reported in literature and it may be the first one reported from India.

Plexiform schwannoma arising from the duodenum: a rare condition

“…They are benign, non-infiltrating tumors with limited or no local recurrence and no ability to metastasize to other organs, so the prognosis is favorable. 1,4,8,9 In conclusion, plexiform schwannoma is a rare entity that tends to settle in soft tissues of the head and neck, being infrequent visceral involvement. These are well-defined single lesions with marked hypercellularity and positive for S-100.…”

Plexiform schwannoma arising from the duodenum: a rare condition

“…They are benign, non-infiltrating tumors with limited or no local recurrence and no ability to metastasize to other organs, so the prognosis is favorable. 1,4,8,9 In conclusion, plexiform schwannoma is a rare entity that tends to settle in soft tissues of the head and neck, being infrequent visceral involvement. These are well-defined single lesions with marked hypercellularity and positive for S-100.…”

Unusual Lower Lip Swelling: A Rare Case of Lip Schwannoma

“…Furthermore, schwannomas of the lip produce apparent visual deformity for the patient and induce mental discomfort [11,12]. Because this tumor is uncommon in the lips, a diagnosis of lip schwannoma is sometimes ignored until it has progressed to more advanced stages of growth and cosmetic disfigurement [9,13]. Because of the delicate neuronal anatomy within the vast neuronal innervation of the lips, surgical removal of schwannomas in the lips is intrinsically difficult, depending on the size and exact location of the lesion, and even minor injury during excision can result in considerable morbidities such as impaired speech, dysarthria, aspiration, paresthesia, and dysphagia [14][15][16].…”

Relationship between Tumor Diameters and Antoni Classification for Schwannoma of the Lower Lip

“…A search of the literature identified 11 cases of schwannoma of the lower lip, including the present case, and excluding duplicate reports [3][4][5][6][7][8][9] (Table 1). Age at the time of schwannoma diagnosis ranged from 7 to 69 years (mean, 30.1 years).…”

Plexiform schwannoma arising from the duodenum: a rare condition

“…They are benign, non-infiltrating tumors with limited or no local recurrence and no ability to metastasize to other organs, so the prognosis is favorable. 1,4,8,9 In conclusion, plexiform schwannoma is a rare entity that tends to settle in soft tissues of the head and neck, being infrequent visceral involvement. These are well-defined single lesions with marked hypercellularity and positive for S-100.…”

Unusual Lower Lip Swelling: A Rare Case of Lip Schwannoma

“…Furthermore, schwannomas of the lip produce apparent visual deformity for the patient and induce mental discomfort [11,12]. Because this tumor is uncommon in the lips, a diagnosis of lip schwannoma is sometimes ignored until it has progressed to more advanced stages of growth and cosmetic disfigurement [9,13]. Because of the delicate neuronal anatomy within the vast neuronal innervation of the lips, surgical removal of schwannomas in the lips is intrinsically difficult, depending on the size and exact location of the lesion, and even minor injury during excision can result in considerable morbidities such as impaired speech, dysarthria, aspiration, paresthesia, and dysphagia [14][15][16].…”

Relationship between Tumor Diameters and Antoni Classification for Schwannoma of the Lower Lip

“…A search of the literature identified 11 cases of schwannoma of the lower lip, including the present case, and excluding duplicate reports [3][4][5][6][7][8][9] (Table 1). Age at the time of schwannoma diagnosis ranged from 7 to 69 years (mean, 30.1 years).…”

Plexiform schwannoma arising from the duodenum: a rare condition

“…They are benign, non-infiltrating tumors with limited or no local recurrence and no ability to metastasize to other organs, so the prognosis is favorable. 1,4,8,9 In conclusion, plexiform schwannoma is a rare entity that tends to settle in soft tissues of the head and neck, being infrequent visceral involvement. These are well-defined single lesions with marked hypercellularity and positive for S-100.…”

Unusual Lower Lip Swelling: A Rare Case of Lip Schwannoma

“…Furthermore, schwannomas of the lip produce apparent visual deformity for the patient and induce mental discomfort [11,12]. Because this tumor is uncommon in the lips, a diagnosis of lip schwannoma is sometimes ignored until it has progressed to more advanced stages of growth and cosmetic disfigurement [9,13]. Because of the delicate neuronal anatomy within the vast neuronal innervation of the lips, surgical removal of schwannomas in the lips is intrinsically difficult, depending on the size and exact location of the lesion, and even minor injury during excision can result in considerable morbidities such as impaired speech, dysarthria, aspiration, paresthesia, and dysphagia [14][15][16].…”

Relationship between Tumor Diameters and Antoni Classification for Schwannoma of the Lower Lip

“…A search of the literature identified 11 cases of schwannoma of the lower lip, including the present case, and excluding duplicate reports [3][4][5][6][7][8][9] (Table 1). Age at the time of schwannoma diagnosis ranged from 7 to 69 years (mean, 30.1 years).…”