A rare case of ovarian carcinosarcoma with squamous cell carcinoma

Daimon, Atsushi; Fujiwara, Satoe; Tanaka, Yoshimichi; Tanaka, Tomohito; Ohmichi, Masahide

doi:10.1186/s13048-019-0507-3

Cited by 8 publications

(17 citation statements)

References 12 publications

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“…One case reported by Vernadakis et al [ 3 ] showed a giant mass of 33 × 22 × 10 cm in size containing both solid and cystic elements. In our study, the five tumors were unilateral, cystic-solid masses, and the largest transverse diameter ranged from 11 cm to 14 cm, which was similar to reports indicating that the size of masses generally [ 3 , 4 , 6 , 13 , 14 ].…”

Section: Discussionsupporting

confidence: 90%

“…Many ovarian tumors manifest as large pelvic masses. Clinical, some studies showed that patients with OCS are more likely to present with a unilateral, large pelvic mass [ 4 , 6 , 13 ]. The radiological findings of OCS are not well known, as few studies have described the imaging feature of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…The radiological findings of OCS are not well known, as few studies have described the imaging feature of the disease. Daimon et al [ 6 ] reported a case of this tumor showing a multilocular mixed cystic-solid masses with a diameter of 27 cm, and the solid part of the tumor was hemorrhage. Uçar et al [ 4 ] reported a large solid, well-circumscribed mass of OCS measuring 18 cm in the largest transverse diameter.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, OCS are highly aggressive tumors with rapid progression and poor prognosis [ 6 , 15 , 16 ]. Advanced stage at presentation, suboptimal surgical resection and older age are associated with poor prognosis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

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Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases

Zhang

Zou

2020

J Ovarian Res

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Background Ovarian carcinosarcomas (OCS) are very rare tumors composed of a mixture of carcinomatous and sarcomatous elements. There have been only scattered case studies that have described the imaging findings. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinical and imaging features of five cases of OCS confirmed by surgical pathologic evaluation. Methods This retrospective study includes five OCS patients diagnosed and treated at our institute. The clinical course and imaging findings of all patients were retrospectively analyzed. The patients were 31 to 59 years of age. All five patients underwent CT scans, two underwent MRI scans. Results The five patients have no specific symptoms. Four patients had elevated CA 125 levels and three patients had elevated CA 153 levels. All patients had unilateral tumors, four in the left ovary, one in the right ovary. The largest transverse diameter of the tumors ranged from 11 cm to 14 cm. Two tumors showed solid masses with unequally sized cystic areas or necrosis, one showed a multilocular cystic mass with a large solid protrusion, two tumors showed a larger cystic mass with multiple mural nodules. The solid components of the tumors demonstrated restricted diffusion (the average ADC value being 998 mm2/s and 1102 mm2/s, respectively), and showed moderate or obvious enhancement. All five patients were treated by surgical resection and adjuvant chemotherapy. One patient is currently undergoing post-operative chemotherapy 1 month after operation and clinical stable. Three patients survived and showed no obvious recurrence and / or metastasis in follow-up from 9 to 59 months. One patient died from recurrence and metastasis. Conclusions OCS are rare and demonstrate variable CT and MRI morphological appearances. Due to the heterogeneous nature and very low morbidity of OCS, combination of careful analysis of imaging findings and clinical features might be useful for a more accurate diagnosis of OCS.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases

Zhang

Zou

2020

J Ovarian Res

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“…Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumour (MMMT), is one of the rarest histological subtypes of ovarian cancer. OCS represents 1–4% of all ovarian tumours [ 2 , 3 ]. OCS can be found in the genito-urinary tract with the most common site being the uterus, followed by the ovary, fallopian tubes, cervix, vagina, peritoneum, breast and urethra [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Carcinosarcoma with Retroperitoneal Para-Aortic Lymph Node Dissemination Followed by an Unusual Postoperative Complication: A Case Report with a Brief Literature Review

et al. 2020

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Introduction. Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumour (MMMT), is one of the rarest histological subtypes of ovarian cancer. It is an aggressive tumour with a dismal prognosis—the median survival of patients is less than two years. The rarity of the disease generates many controversies about histogenesis, prognostic factors and treatment of OCS. Histologically, OCS is composed of an epithelial and sarcomatous component. Case report. In the present case, a patient with bilateral ovarian cysts and bulky paraaortic lymph nodes is reported. Retroperitoneal paraaortic lymph node metastases were the only extrapelvic dissemination of OCS. The patient underwent comprehensive surgical staging procedures, including total abdominal hysterectomy and bilateral salpingo-oophorectomy, supracolic omentectomy and selective para-aortic lymphadenectomy. Histologically the ovarian carcinosarcoma was composed of an epithelial component (high-grade serous adenocarcinoma) and three sarcomatous components (homologous—endometrial stromal cell sarcoma, and heterologous—chondrosarcoma, rhabdomyosarcoma). Immunohistochemistry staining was performed. A postoperative complication (adhesion between the abdominal aorta and terminal ileum causing obstructive ileus) that has never been reported in the medical literature occurred. Conclusion. Carcinosarcomas are carcinomas with epithelial–mesenchymal transition and heterologous differentiation. Retroperitoneal pelvic and paraaortic lymph nodes should be carefully inspected in patients with ovarian tumours. Adhesions between the small bowels and abdominal aorta are possible complications after lymph node dissection in the paraaortic region.

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