A Rare Case of Dandy-Walker Syndrome

Oria, Mohammad Sharif; Rasib, Aziz Rahman; Pirzad, Ahmad Fawad; Khel, Fahima Wali Ibrahim; Khel, Mohammad Ismael Ibrahim; Wardak, Fazel Rahim

doi:10.2147/imcrj.s350858

Cited by 7 publications

(6 citation statements)

References 17 publications

(28 reference statements)

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“…DWM is a congenital brain anomaly and over 85% of cases are discovered before the age of 1 year. Five researchers have reported that the incidence of hydrocephalus was between 86% and 94% in numerous prior studies [13] . Prenatal regular sonography throughout the antenatal period has helped some obstetricians discover this malformation [14] .…”

Section: Discussionmentioning

confidence: 99%

Cerebral, ocular, dental, auricular, skeletal anomalies (CODAS) syndrome: First case reported in Saudi Arabia

Mousa

Taher

Sharif

et al. 2023

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Cerebral, ocular, dental, auricular, skeletal anomalies (CODAS) syndrome: First case reported in Saudi Arabia

Mousa

Taher

Sharif

et al. 2023

Radiology Case Reports

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“…It has been suggested that geographical location, climate, and nutritional habits all play important roles in T. gondii survival and spread (Foroutan et al, 2018). Oria et al, (2022) described a case of Dandy-Walker syndrome in a 16-year-old female patient in Kabul, which might be caused by T. gondii infection (Hamid, 2007;Ndu et al, 2015). Kozojed et al (1976) reported a high seroprevalence of toxoplasmosis (15.7 -73.7%) in domestic animals (camels, zebus, goats, sheep, buffalos and cattle).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and Risk Factors of Human Brucellosis and Toxoplasmosis in Ghazni Province of Afghanistan

Abdali¹,

Samadi²

2022

VMPH

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Brucellosis and toxoplasmosis are considered neglected zoonotic diseases with a worldwide distribution, which are endemic in Afghanistan. A cross-sectional study was carried out from May 24, 2021, to Feb 20, 2022 to determine the seroprevalence and risk factors associated with human brucellosis and toxoplasmosis in suspected patients admitted to the public and private laboratories of Ghazni province of Afghanistan. To detect Brucella IgM. a semi-quantitative agglutination test was used, while for the detection of Toxoplasma IgM and IgG, a chromatographic immunoassay was applied. Seroprevalence of brucellosis and toxoplasmosis were 32.1% (76/237) and 19.6% (18/92) in tested patients, respectively. Whereas, only in five cases dual infections were found. The majority of brucellosis positive cases were among the age group >45 years old (57.1%; p<0.05), in district residents (43.5%; p>0.05), and among those with abortion (30.6%; p<0.05) and history of positive brucellosis cases (50.0%; p<0.05) in their family members. High seropositive cases of toxoplasmosis were observed in males (50.0%; p>0.05), 21-45 years old people (20.8%; p>0.05), those who owned dogs and cats (p>0.05), among those with the history of abortion cases in their animals (41.7%; p<0.05), and positive toxoplasmosis cases in their family members (66.7.0%; p≤0.05). The odds of being seropositive for brucellosis was higher in those that had history of abortion (OR: 4.3; 95%CI: 1.3-4.2) and brucellosis cases (OR: 7.1; 95%CI: 1.7-28.9) among their family members. Furthermore, the odds of being seropositive for toxoplasmosis was 13.2 times more (95%CI: 2.1, 82.2; p<0.05) in those which had history of abortion cases in their animals. The high seroprevalence could be attributed to the study population being drawn from suspected cases rather than the general population. To assess the cross-connection of infections in human and animal populations, it would be more beneficial to study a large number of human and animal samples concurrently.

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“…The prognosis depends on intra/extracranial malformations, being unfavorable for those who present these malformations, which are 50-70% of patients, with a mortality of 70% in fetuses, 14% in neonates, and 25% in infants. And favorable towards normal development within 50-65% of cases (1).…”

Section: Introductionmentioning

confidence: 94%

Hydrocephalus and Dandy-Walker syndrome. Clinical case

Villalobos-Rodríguez

2023

AJMCRR

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Introduction. Dandy-Walker syndrome (DWS) is a developmental abnormality characterized by dilated posterior fossa, cystic enlargement of the fourth ventricle, hypoplasia of cerebellar vermis, and its upward rotation. The affected person may suffer from psychomotor retardation, ataxia, apnea attacks, muscle weakness, occasional muscle spasm, seizures, nystagmus, and macrocephaly. However, half of the cases have average intelligence. Clinical Case. Male newborn at 36 weeks gestation obtained by cesarean section, with a history in the current pregnancy of poor prenatal control. During the fifth month of pregnancy, an ultrasound established a diagnostic suspicion of massive ventriculomegaly. At the sixth month, thinning of the cerebral cortex compression of the cerebellum in the posterior fossa was detected, and a possible ruling out of chromosomopathy related to Dandy-Walker Syndrome was suggested. Discussion. Neurologically, this disease causes multiple anomalies, such as Hemorrhagic Stroke in a Young Adult with Undiagnosed Asymptomatic Dandy–Walker Malformation (5). The embryonic development of the cerebellum and fourth ventricle causes the tentorium to be displaced upwards, and the posterior fossa enlarges. The association of hydrocephalus with DWS is due to blockage of normal cerebrospinal flow, leading to an excessive amount of fluid accumulating in and around the brain and causing an increase in intracranial pressure and head circumference, which ultimately causes neurological impairment. Conclusions. The prognosis of patients with this syndrome depends on the association with intra/extracranial malformations. Early diagnosis of central nervous system abnormalities is considered one of the first objectives of obstetric ultrasound.

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A Rare Case of Dandy-Walker Syndrome

Cited by 7 publications

References 17 publications

Cerebral, ocular, dental, auricular, skeletal anomalies (CODAS) syndrome: First case reported in Saudi Arabia

Cerebral, ocular, dental, auricular, skeletal anomalies (CODAS) syndrome: First case reported in Saudi Arabia

Seroprevalence and Risk Factors of Human Brucellosis and Toxoplasmosis in Ghazni Province of Afghanistan

Hydrocephalus and Dandy-Walker syndrome. Clinical case

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