A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: A pilot study

Blackwood, David P.; LaVallée, R.K.; Busaidi, A. Al; Jassal, Davinder S.; Pierce, Grant N.

doi:10.1016/j.clnesp.2015.07.002

Cited by 4 publications

(13 citation statements)

References 24 publications

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“…Among the full‐text articles evaluated, 24 studies were excluded for the following reasons: duplicate report ( n = 2), not randomized placebo‐controlled studies ( n = 2), no anthropometric measurements performed ( n = 17) and use of flaxseed in combination with other components without an appropriate control group ( n = 3). Forty‐five eligible RCTs with 49 treatment arms were included in the meta‐analyses . Of these, 28 articles reported effects of flaxseed on weight , 35 articles on BMI and 13 articles on WC .…”

Section: Resultsmentioning

confidence: 99%

“…Nine of the 45 trials were performed exclusively on women and nine on men , and the remaining trials included both sexes; however, three studies did not mention sex composition of participants . Eligible studies were published between 1995 and 2016, and most of them were conducted in the USA , Canada , Iran and Brazil . The remaining studies were conducted in China , Australia , Greece , Germany , Denmark , Romania India and Japan .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two treatment arms used whole , ground or deffated flaxseed for the intervention. Sunflower seed , raw rice , collagen , wheat germ , manioc flour , cassava flour , wheat bran and wheat were used for the control groups.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐nine trials were classified as high quality (Jadad score ≥ 3) , and 16 trials were of low quality (Jadad score < 3) . The last column of Table provides the quality assessment results of the studies.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty‐two studies did not adequately explain the randomization procedure . Twenty studies reported double blinding , but 28 studies did not clearly describe the blinding procedure . Details of dropouts were provided in all the studies.…”

Section: Resultsmentioning

confidence: 99%

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The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials

et al. 2017

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Summary Flaxseed consumption may be inversely associated with obesity; however, findings of available randomized controlled trials (RCTs) are conflicting. The present study aimed to systematically review and analyse RCTs assessing the effects of flaxseed consumption on body weight and body composition. PubMed, Medline via Ovid, SCOPUS, EMBASE and ISI Web of Sciences databases were searched up to November 2016. Mean changes in body composition indices including body weight, body mass index (BMI) and waist circumference were extracted. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Heterogeneity between studies was assessed with the I2 test. Publication bias and subgroup analyses were also performed. The quality of articles was assessed via the Jadad scale. A total of 45 RCTs were included. Meta‐analyses suggested a significant reduction in body weight (WMD: −0.99 kg, 95% CI: −1.67, −0.31, p = 0.004), BMI (WMD: −0.30 kg m−2, 95% CI: −0.53, −0.08, p = 0.008) and waist circumference (WMD: −0.80 cm, 95% CI: −1.40, −0.20, p = 0.008) following flaxseed supplementation. Subgroup analyses showed that using whole flaxseed in doses ≥30 g d−1, longer‐term interventions (≥12 weeks) and studies including participants with higher BMI (≥ 27 kg m−2) had positive effects on body composition. Whole flaxseed is a good choice for weight management particularly for weight reduction in overweight and obese participants.

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Section: Resultsmentioning

confidence: 99%