2012
DOI: 10.1158/1055-9965.epi-12-0075
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Abstract: Background: Patients with lymphoma experience sleep problems that may be managed with aerobic exercise but no previous study has examined this issue.Methods: We randomized 122 patients with lymphoma to usual care (n ¼ 62) or 12 weeks of supervised aerobic exercise training (AET; n ¼ 60). Our primary sleep endpoint was global sleep quality assessed by the Pittsburgh Sleep Quality Index (PSQI). Secondary endpoints were the PSQI component scores. Planned subgroup analyses were also conducted.Results: Intention-to… Show more

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Cited by 43 publications
(42 citation statements)
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“…It should be noted that a higher PSQI score reflects worse sleep quality, so a positive change score (4-month – baseline) would indicate worsening sleep quality over time. Although there are no defined criteria for a “clinically significant” difference in PSQI score, our effect size was similar to that of other insomnia treatment studies[14-16] and almost equivalent to one standard deviation for the total PSQI score within our study population. As stated previously, 43% of patients on placebo and 56% on melatonin were classified as poor sleepers at baseline based upon the global PSQI score cutoff of 5 or more points.…”
Section: Resultssupporting
confidence: 84%
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“…It should be noted that a higher PSQI score reflects worse sleep quality, so a positive change score (4-month – baseline) would indicate worsening sleep quality over time. Although there are no defined criteria for a “clinically significant” difference in PSQI score, our effect size was similar to that of other insomnia treatment studies[14-16] and almost equivalent to one standard deviation for the total PSQI score within our study population. As stated previously, 43% of patients on placebo and 56% on melatonin were classified as poor sleepers at baseline based upon the global PSQI score cutoff of 5 or more points.…”
Section: Resultssupporting
confidence: 84%
“…Importantly for breast cancer survivors, we have previously demonstrated that melatonin does not have any adverse effects on circulating estradiol or IGF-1 levels. [9] Although there are no defined criteria for a “clinically significant” change in PSQI score, the magnitude of the effect we observed was similar to other studies of pharmacologic and lifestyle treatments of insomnia[14-16] and almost equivalent to one standard deviation for the total PSQI score within our study population. When looking specifically at poor sleepers, there appeared to be more improvement qualitatively in the melatonin arm.…”
Section: Discussionsupporting
confidence: 86%
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“…As noted by the International Harmonization Project [7], the clinical benefit of a therapy for lymphoma patients depends not only on the magnitude of its effect on PFS, but also on its impact on other important endpoints including quality of life and symptom management. Given the meaningful effects of exercise on health-related fitness, quality of life, depression, fatigue, and sleep quality already reported in lymphoma patients [2,15], even a small effect of exercise on PFS would make it a compelling intervention based on overall clinical benefit. Additional research examining the clinical benefits of exercise in lymphoma patients, including survival outcomes, is warranted.…”
Section: Discussionmentioning
confidence: 99%
“…Providing properly prescribed exercise for people with cancer has many benefits that are well described in the literature. 7,8 There is evidence of the benefits of exercise and physiotherapy intervention throughout the cancer-care continuum, including palliative care. 9-11 While physiotherapists focus on mobility and quality of life, it is important to remember that physiotherapy interventions can also affect survival: there is evidence that exercise can improve survival, reduce recurrence, and reduce overall mortality in women with breast cancer who exercise after diagnosis.…”
mentioning
confidence: 99%