A Randomized Placebo-Controlled Trial of Cysteamine Eye Drops in Nephropathic Cystinosis

A randomised placebo-controlled trial of topical cysteamine therapy in patients with nephropathic cystinosis

“…The visual acuity improvement may be largely due to the improvement in photophobia and blepharos pasm rather than an improvement in corneal transparency. Both objective and subjective improvements in visual acuity have been shown by other authors (3,4,5).…”

“…In all cases subjective improvement occurred before objective improvements in visual function. Improvement in ocular symp tomatology have been noted by other authors as the first change seen in topical cysteamine therapy (5). A possible explanation is that the ocular discomfort is due to severe anterior stromal disease stimulating the sensory nerve endings at the level of the basal epithelial cells.…”

A randomised placebo-controlled trial of topical cysteamine therapy in patients with nephropathic cystinosis

“…The visual acuity improvement may be largely due to the improvement in photophobia and blepharos pasm rather than an improvement in corneal transparency. Both objective and subjective improvements in visual acuity have been shown by other authors (3,4,5).…”

“…In all cases subjective improvement occurred before objective improvements in visual function. Improvement in ocular symp tomatology have been noted by other authors as the first change seen in topical cysteamine therapy (5). A possible explanation is that the ocular discomfort is due to severe anterior stromal disease stimulating the sensory nerve endings at the level of the basal epithelial cells.…”

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

“……”

Ocular manifestations of intermediate cystinosis: To treat or not to treat?

“…3,6,15,22 It is known that topical cysteamine is a therapeutic option against corneal disease causing a reduction of cystine crystals density and diminishing symptoms like photophobia. 23,24 However, treatment compliance is poor as there is a need for multiple instillations for a long period of time. Quality of life must always be addressed in all these cases as the frequent and chronic instillation of eye drops may bring significant distress to patient’s daily life when compared with the usefulness of such treatment options.…”

A randomised placebo-controlled trial of topical cysteamine therapy in patients with nephropathic cystinosis

“…The visual acuity improvement may be largely due to the improvement in photophobia and blepharos pasm rather than an improvement in corneal transparency. Both objective and subjective improvements in visual acuity have been shown by other authors (3,4,5).…”

“…In all cases subjective improvement occurred before objective improvements in visual function. Improvement in ocular symp tomatology have been noted by other authors as the first change seen in topical cysteamine therapy (5). A possible explanation is that the ocular discomfort is due to severe anterior stromal disease stimulating the sensory nerve endings at the level of the basal epithelial cells.…”

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

“……”

Ocular manifestations of intermediate cystinosis: To treat or not to treat?

“…3,6,15,22 It is known that topical cysteamine is a therapeutic option against corneal disease causing a reduction of cystine crystals density and diminishing symptoms like photophobia. 23,24 However, treatment compliance is poor as there is a need for multiple instillations for a long period of time. Quality of life must always be addressed in all these cases as the frequent and chronic instillation of eye drops may bring significant distress to patient’s daily life when compared with the usefulness of such treatment options.…”

A randomised placebo-controlled trial of topical cysteamine therapy in patients with nephropathic cystinosis

“…The visual acuity improvement may be largely due to the improvement in photophobia and blepharos pasm rather than an improvement in corneal transparency. Both objective and subjective improvements in visual acuity have been shown by other authors (3,4,5).…”

“…In all cases subjective improvement occurred before objective improvements in visual function. Improvement in ocular symp tomatology have been noted by other authors as the first change seen in topical cysteamine therapy (5). A possible explanation is that the ocular discomfort is due to severe anterior stromal disease stimulating the sensory nerve endings at the level of the basal epithelial cells.…”

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

“……”

Ocular manifestations of intermediate cystinosis: To treat or not to treat?

“…3,6,15,22 It is known that topical cysteamine is a therapeutic option against corneal disease causing a reduction of cystine crystals density and diminishing symptoms like photophobia. 23,24 However, treatment compliance is poor as there is a need for multiple instillations for a long period of time. Quality of life must always be addressed in all these cases as the frequent and chronic instillation of eye drops may bring significant distress to patient’s daily life when compared with the usefulness of such treatment options.…”