A Randomized, Placebo-Controlled, Double-blind Trial Comparing Narrowband UV-B Plus 0.1% Tacrolimus Ointment With Narrowband UV-B Plus Placebo in the Treatment of Generalized Vitiligo

Vitiligo: A comprehensive overview

“…30 Topical CIs work well as adjunctive therapy. Although a small randomized, double-blinded placebo controlled trial found no benefit for adding topical tacrolimus to NBUVB phototherapy, 31 others have shown repigmentation rates of more than 50% in 42% of lesions in patients with chronic stable refractory vitiligo 32 and that combination therapy can provide additional benefit for facial lesions. 33 Studies combining topical tacrolimus with the 308-nm excimer laser have shown even more promising results.…”

“…Common side effects include erythema, pruritis, burning, and irritation 6,14,22,24,31 ; hyperpigmentation and acne are less frequent. [35][36][37] As a precautionary measure, the product label revisions approved by the US Food and Drug Administration (FDA) for topical CIs in January 2006 were based on a theoretical risk arising from the systemic use of CIs in transplant recipients and animal studies.…”

Narrowband ultraviolet B phototherapy and 308-nm excimer laser in the treatment of vitiligo: A review

“…7 Based on the report by Westerhof and NieuweboerKrobotova, 6 the guidelines for the treatment of vitiligo 8 that were published in 1999eand have not been revised yeteproposed NB-UVB as first-choice therapy for generalized vitiligo in adults and as alternative therapy, after class-III corticosteroids, for vitiligo in children. In the following years, several studies assessed the efficacy of NB-UVB alone 3,[9][10][11][12][13][14][15][16][17][18] or in combination with other agents [19][20][21][22][23][24][25][26][27][28][29][30][31] in the treatment of vitiligo with variable results. A number of studies [32][33][34][35] have also compared the efficacy of NB-UVB with that of PUVA in patients with vitiligo and have reported comparable or slightly better efficacy for NB-UVB.…”

Vitiligo Management- An Update

“…Treatment options that have been used with NB-UVB in vitiligo till date include topical tacrolimus, 14,15 pimecrolimus, 16 Vitamin D analogues 17,18 and even topical pseudocatalase 19 . While some studies have shown a synergistic effect with these combinations, others have found the efficacy of the combinations to be similar to NB-UVB alone.…”