A Randomized, Masked, Crossover Trial of Acetazolamide for Cystoid Macular Edema in Patients with Uveitis

Central visual field impairment during and following cystoid macular oedema

“…This fact together with strict selection criteria suggests that the characteristics of retinal sensitivity impairment can be attributed to the CMO and are not biased by other factors. Visual acuities reported in our study are better than those of other reports,12 19 20 but this is most likely because of our strict patient selection and thus should not be compared with other studies. Although time-consuming, patients with CMO should be examined using more sensitive tests than merely assessing distance VA, as it seems that higher-order visual functions such as reading are more intensively affected by macular disease than standard distance VA. Our group could show that CMO impairs the ability to read as a higher-order visual function more than the discrimination of single optotypes 14.…”

Central visual field impairment during and following cystoid macular oedema

“…This fact together with strict selection criteria suggests that the characteristics of retinal sensitivity impairment can be attributed to the CMO and are not biased by other factors. Visual acuities reported in our study are better than those of other reports,12 19 20 but this is most likely because of our strict patient selection and thus should not be compared with other studies. Although time-consuming, patients with CMO should be examined using more sensitive tests than merely assessing distance VA, as it seems that higher-order visual functions such as reading are more intensively affected by macular disease than standard distance VA. Our group could show that CMO impairs the ability to read as a higher-order visual function more than the discrimination of single optotypes 14.…”

Pseudophakic Macular Edema and Oral Acetazolamide: An Optical Coherence Tomography Measurable, Dose-Related Response

“…In a patient with endophthalmitis postcataract surgery, an alternative explanation would be the compromised retinal pigment epithelium function from toxin release. However, the documented improvement in visual acuity and CFT with acetazolamide would suggest that retinal edema in this case is secondary to cataract surgery rather than being uveitic in origin (4). This is also supported by the absence of intraocular inflammation throughout the postop-erative course from about 2 months postoperatively, and the response to acetazolamide without the addition of local or systemic corticosteroid therapy.…”

Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis

“…Results, however, have been controversial. Whereas in some studies patients responded favorably, Whitcup et al demonstrated a significant reduction of CME -0.5disc area (25%) decrease -in a randomized, masked cross-over trial in 37 patients with posterior uveitis or panuveitis but no beneficial effect on VA [8,13,14,32,37]. A major drawback of this therapy -as in some of our patients -.-is the high rate of side effects, such as nausea, diarrhea and paresthesia, that adversely affect compliance.…”

Central visual field impairment during and following cystoid macular oedema

“…This fact together with strict selection criteria suggests that the characteristics of retinal sensitivity impairment can be attributed to the CMO and are not biased by other factors. Visual acuities reported in our study are better than those of other reports,12 19 20 but this is most likely because of our strict patient selection and thus should not be compared with other studies. Although time-consuming, patients with CMO should be examined using more sensitive tests than merely assessing distance VA, as it seems that higher-order visual functions such as reading are more intensively affected by macular disease than standard distance VA. Our group could show that CMO impairs the ability to read as a higher-order visual function more than the discrimination of single optotypes 14.…”

Pseudophakic Macular Edema and Oral Acetazolamide: An Optical Coherence Tomography Measurable, Dose-Related Response

“…In a patient with endophthalmitis postcataract surgery, an alternative explanation would be the compromised retinal pigment epithelium function from toxin release. However, the documented improvement in visual acuity and CFT with acetazolamide would suggest that retinal edema in this case is secondary to cataract surgery rather than being uveitic in origin (4). This is also supported by the absence of intraocular inflammation throughout the postop-erative course from about 2 months postoperatively, and the response to acetazolamide without the addition of local or systemic corticosteroid therapy.…”

Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis

“…Results, however, have been controversial. Whereas in some studies patients responded favorably, Whitcup et al demonstrated a significant reduction of CME -0.5disc area (25%) decrease -in a randomized, masked cross-over trial in 37 patients with posterior uveitis or panuveitis but no beneficial effect on VA [8,13,14,32,37]. A major drawback of this therapy -as in some of our patients -.-is the high rate of side effects, such as nausea, diarrhea and paresthesia, that adversely affect compliance.…”

Central visual field impairment during and following cystoid macular oedema

“…This fact together with strict selection criteria suggests that the characteristics of retinal sensitivity impairment can be attributed to the CMO and are not biased by other factors. Visual acuities reported in our study are better than those of other reports,12 19 20 but this is most likely because of our strict patient selection and thus should not be compared with other studies. Although time-consuming, patients with CMO should be examined using more sensitive tests than merely assessing distance VA, as it seems that higher-order visual functions such as reading are more intensively affected by macular disease than standard distance VA. Our group could show that CMO impairs the ability to read as a higher-order visual function more than the discrimination of single optotypes 14.…”

Pseudophakic Macular Edema and Oral Acetazolamide: An Optical Coherence Tomography Measurable, Dose-Related Response

“…In a patient with endophthalmitis postcataract surgery, an alternative explanation would be the compromised retinal pigment epithelium function from toxin release. However, the documented improvement in visual acuity and CFT with acetazolamide would suggest that retinal edema in this case is secondary to cataract surgery rather than being uveitic in origin (4). This is also supported by the absence of intraocular inflammation throughout the postop-erative course from about 2 months postoperatively, and the response to acetazolamide without the addition of local or systemic corticosteroid therapy.…”

Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis

“…Results, however, have been controversial. Whereas in some studies patients responded favorably, Whitcup et al demonstrated a significant reduction of CME -0.5disc area (25%) decrease -in a randomized, masked cross-over trial in 37 patients with posterior uveitis or panuveitis but no beneficial effect on VA [8,13,14,32,37]. A major drawback of this therapy -as in some of our patients -.-is the high rate of side effects, such as nausea, diarrhea and paresthesia, that adversely affect compliance.…”