A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia

Suchonwanit, Poonkiat; Rojhirunsakool, Salinee; Khunkhet, Saranya

doi:10.1007/s10103-019-02783-8

Cited by 47 publications

(53 citation statements)

References 28 publications

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“…2 It is characterized by a progressive miniaturization of hair follicles limited to the frontotemporal and vertex areas, considered to be androgen-sensitive scalp regions. [3][4][5] The pathogenesis of male AGA remains unclear; however, dihydrotestosterone (DHT), the main androgen converted from testosterone by 5-alpha reductase (5-AR), is thought to play an important role. DHT acts on androgen receptors (AR), causing terminal hairs to convert to miniaturized hairs, eventually resulting in AGA.…”

Section: Introductionmentioning

confidence: 99%

Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

Chanprapaph

Sutharaphan

Suchonwanit

2021

CIA

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Background: Androgenetic alopecia (AGA) is the most common type of hair loss in men. Its prevalence increases with advancing age. Characteristics of hair loss in male AGA reveal the possibility of different biophysical and physiological profiles between androgen-sensitive (vertex) and androgen-insensitive (occipital) scalps. However, these variations have not been well investigated. Objective: We aimed to evaluate and compare scalp biophysical and physiological characteristics in male AGA patients and healthy controls. Methods: Scalp biophysiological profiles were evaluated by non-invasive measuring techniques, including skin surface lipids (SSL), transepidermal water loss (TEWL), and stratum corneum hydration (SCH) on both vertex and occipital areas. Values were compared between scalp areas and study groups. Participants with AGA were further categorized based on disease severity (Hamilton-Norwood classification) for subgroup analyses. Correlation coefficients were evaluated to determine the effects of AGA severity and age on each functional parameter. Results: Participants were 31 AGA subjects and 31 healthy controls. The vertex scalp of AGA patients had significantly higher SSL (p = 0.03) and lower SCH (p = 0.02) compared to the occipital scalp. TEWL was not significantly different (p = 0.31). AGA group SSL showed a positive correlation with severity of hair loss (r = 0.61, p = 0.03). When compared to controls, the AGA group vertex scalp had significantly higher SSL (p = 0.03) and lower TEWL (p < 0.001). The occipital area showed no statistically significant differences. Conclusion: Male AGA presents with different biophysical and physiological characteristics in androgen-sensitive and androgen-insensitive areas, and with further differences from controls. These findings could direct further research and aid in the development of optimal hair and scalp treatments to improve scalp functional profiles in particular patients.

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Section: Introductionmentioning

confidence: 99%

Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

Chanprapaph

Sutharaphan

Suchonwanit

2021

CIA

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“…Table 1 summarizes all reported cases of PR-like eruption following COVID-19 vaccination. Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12,(15)(16)(17)(18). Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination

2021

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Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. However, several adverse effects of COVID-19 vaccination have been identified. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations.

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“…Lastly, usage of LCD cream or other coal tar derivatives can interfere with UV transmission and should be removed thoroughly before exposure to phototherapy (28)(29)(30)(31)(32). Although the detail of photodynamic activity of coal tar was still unclear and only proven with an action spectrum in UVA and visible light (33,34), several studies had demonstrated the effectiveness of coal tar in enhancing the therapeutic outcome of UVB spectrum treatment similar to our study suggesting rooms for further research in elucidating the actual mechanism and possible light spectrum range for UVB of coal tar photodynamic activity (13,(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

308-nm Excimer Lamp vs. Combination of 308-nm Excimer Lamp and 10% Liquor Carbonis Detergens in Patients With Scalp Psoriasis: A Randomized, Single-Blinded, Controlled Trial

et al. 2021

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Background: Scalp psoriasis is usually refractory to treatment. Excimer devices have been proved to be a promising therapeutic option in psoriasis. Greater efficacy of phototherapy can be achieved by concurrent use of coal tar derivatives.Objective: We aimed to compare efficacy and safety between 308-nm excimer lamp monotherapy and a combination of 308-nm excimer lamp and 10% liquor carbonis detergens in the treatment of scalp psoriasis.Methods: In this randomized, evaluator-blinded, prospective, comparative study, 30 patients with scalp psoriasis received either 308-nm excimer lamp monotherapy or a combination of 308-nm excimer lamp and 10% liquor carbonis detergens twice per week until complete remission of the scalp or for a total of 30 sessions. Efficacy was evaluated by the improvement of Psoriasis Scalp Severity Index (PSSI) score, itch score, and Scalpdex score.Results: Both treatments induced significant improvement in PSSI score with greater reduction observed in the combination group. At 30th visit, a 75% reduction in PSSI (PSSI75) was attained by 4 (28.6%) and 9 (69.2%) patients treated with monotherapy and combination therapy, respectively (P < 0.05).Conclusions: Excimer lamp is well-tolerated in patients with scalp psoriasis and liquor carbonis detergens can be used as a combination therapy to improve the efficacy of excimer lamp.

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A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia

Cited by 47 publications

References 28 publications

Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination

308-nm Excimer Lamp vs. Combination of 308-nm Excimer Lamp and 10% Liquor Carbonis Detergens in Patients With Scalp Psoriasis: A Randomized, Single-Blinded, Controlled Trial

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