A randomized, double-blind, placebo-controlled study of luteal phase dydrogesterone (Duphaston ) in women with minimal to mild endometriosist

Identical Ovarian and Deep Pelvic Endometriosis with Colorectal Involvement in Monozygotic Twins: A Case Report and Review of the Literature

“…The results indicate nearly equal distribution among women whose disease stage deteriorated (31%), was unchanged (32%), or improved (38%). In fact, all but one study noted that 23% of placebo patients had complete regression of the disease over intervals of 4 to 39 months, meaning that in over two thirds of women the disease will either persist or progress [26][27][28][29][30][31][32][33]. The clinical presentation of the disease followed a similar trend and evolution in both of our cases.…”

Effects of hormonal treatment on nerve fibers in endometrium and myometrium in women with endometriosis

“…Six to 12 months of treatment with a low-dose OC significantly reduced deep dyspareunia and dysmenorrhea in women with endometriosis (10,11). Women with endometriosis who had dysmenorrhea, dyspareunia, and noncyclic pelvic pain had their pain significantly relieved by norethindrone acetate (12), and treatment with dydrogesterone for 6 months also reduced pelvic pain in women with endometriosis (13). However, the mechanisms by which these therapies reduce pain symptoms are unknown.…”

“…Several studies have demonstrated the efficacy of drugs for endometriosis-associated pain; treatment with an OC, norethindrone, and dydrogesterone significantly reduced pain symptoms including deep dyspareunia, dysmenorrhea, and pelvic pain in women with endometriosis (10)(11)(12)(13).…”

Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue

“…Fertil Steril 2007. decrease in aromatase transcription compared with the case of control animals. Progestational drugs like MPA and dydrogesterone frequently are used primarily to reduce pain that is associated with endometriosis (24,25). Our studies reveal for the first time that those progestins inhibit aromatase transcription in ectopic human endometrial lesions.…”