A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers

An analysis of pain and analgesia after Mohs micrographic surgery

“…The only study to date in which pain scales were administered to patients during Mohs micrographic surgery involves pain surrounding administration of different concentrations of local anesthesia. 5 We initiated a prospective pain assessment study to all patients having Mohs micrographic surgery and investigated tumor location, type of repair, size of defect, age, sex, and pain medications consumed after Mohs micrographic surgery.…”

Local anesthesia using buffered 0.5% lidocaine with 1:200,000 epinephrine for tumors of the digits treated with Mohs micrographic surgery

“…An interesting randomized controlled trial also compared the use of 1% lidocaine with 1:100,000 epinephrine to 0.5% lidocaine with 1:200,000 epinephrine in several body locations and showed equivalent patient comfort, injected volumes, and surgery onset although the lower concentration used half of the total lidocaine dose. 16 Although this study population only involved 5 cases on the hands, feet, and genitalia, and only one of these patients was infiltrated with 0.5% lidocaine, this is the only study in addition to ours that documents the use of this anesthetic concentration during Mohs micrographic surgery. An interesting follow-up study would be to investigate hemostasis and pain control through a randomized controlled trial involving the digits alone, comparing the use of 1% lidocaine with 1:100,000 epinephrine to 0.5% lidocaine with 1:200,000 epinephrine.…”

Successful Management of Hypotension Induced by Low Intracranial Pressure with Intravenous Administration of Lidocaine

“…Lidocaine is the commonly used local anesthetics, which is often adopted in local anesthesia [6], intravenous regional anesthesia [7], and epidural anesthesia [8,9]; meanwhile, it is also used as an antiarrhythmic drug to treat ventricular arrhythmia [10]. Due to its excellent efficacy of surface anesthesia, it has been reported to be used to attenuate the injection pain caused by Propofol and Etomidate with good results [11,12]; it also has been used to prevent the endotracheal suctioning-induced cardiovascular reactions through endotracheal instillation [13]; other reports suggested that Lidocaine by intrathecal injection can relieve the vasoparesis caused by acute neurogenic hypotension and the occurrence of myocardial dysfunction [14].…”