A Randomized Controlled Trial to Assess Sunscreen Application and Beta Carotene Supplementation in the Prevention of Solar Keratoses

Darlington, Steven; Williams, Gail M.; Neale, Rachel E.; Frost, Christine; Green, Adèle C.

doi:10.1001/archderm.139.4.451

Cited by 206 publications

(141 citation statements)

References 16 publications

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“…Una posible explicación a este hecho es la alta movilidad que presentan los pescadores inherente a su labor, lo que implica desplazamientos por distintos puntos geográficos y, por ende, distintos niveles de exposición a la RUV. Existe evidencia que el uso regular de protección solar puede ser efectivo en prevenir la incidencia de QA en la comunidad en general y en la prevención de cán-cer de piel (Darlington et al, 2003).…”

Section: Discussionunclassified

“…Su principal factor etiológico es la exposición a la radiación solar ultravioleta (RUV), especialmente la tipo B, debido a su mayor poder de penetración en comparación a la tipo A (Lopes et al, 2015). Los factores de riesgo asociados son el tabaquismo, personas de piel clara y personas que trabajan al aire libre (de Oliveira Ribeiro et al, 2014). La historia natural de la QA puede seguir cualquiera de las siguientes opciones: regresión espontánea de la lesión, permanecer sin cambios a través del tiempo o evolucionar a un carcinoma espinocelular (CEC) invasivo.…”

Section: Introductionunclassified

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Prevalencia de Queilitis Actínica en Pescadores Artesanales, Valdivia, Chile

Ríos

Maldonado

Norambuena

et al. 2017

Int. J. Odontostomat.

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RÍOS, P.; MALDONADO, C.; NORAMBUENA, P. & DONOSO, M. Prevalencia de queilitis actínica en pescadores artesanales, Valdivia, Chile. Int. J. Odontostomat., 11(2):192-197, 2017. RESUMEN:El objetivo de este trabajo consistió en determinar la prevalencia de Queilitis Actínica en pescadores artesanales de la ciudad de Valdivia, Chile. Se realizó un estudio observacional descriptivo de corte transversal durante los meses de noviembre 2014 a abril 2015. La muestra fueron 180 pescadores previamente seleccionados a través de una muestra aleatoria simple, quienes fueron evaluados mediante un examen clínico y además completaron un cuestionario referente a datos personales y hábitos de salud. El 38,8 % de los pescadores artesanales presentó Queilitis Actínica. El 64,4 % de los pescadores revisados no utiliza protección solar mientras trabaja y todos los casos se ubicaron en el labio inferior. Los pescadores artesanales de la ciudad de Valdivia presentaron una prevalencia de Queilitis Actínica superior a las reportadas a nivel nacional. Nuestros resultados sugieren la implementación de políticas de salud pública centrados en la prevención de Queilitis Actínica en pescadores artesanales de la ciudad de Valdivia.PALABRAS CLAVE: queilitis actínica, pescadores, lesión pre maligna, prevalencia.

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Section: Discussionunclassified

Section: Introductionunclassified

Prevalencia de Queilitis Actínica en Pescadores Artesanales, Valdivia, Chile

Ríos

Maldonado

Norambuena

et al. 2017

Int. J. Odontostomat.

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“…Rate of acquisition of AKs was also reduced in the daily sunscreen group [22], as was the time to subsequent BCCs after the first BCC [23] in the trial period. There was no effect of beta-carotene supplementation on development of actinic tumors, malignant or benign [20,22].…”

Section: Pre-2009 Skin Cancer Prevention Trials and Systematic Reviewsmentioning

confidence: 90%

“…The trial showed that, in comparison with people randomized to using sunscreen at their discretion, if at all, people randomized to daily use of a broad-spectrum SPF15+ sunscreen had no reduction in BCC but a 40 % reduction in SCC tumors at the conclusion of the trial [20]-a reduction maintained 8 years later [21]. Rate of acquisition of AKs was also reduced in the daily sunscreen group [22], as was the time to subsequent BCCs after the first BCC [23] in the trial period. There was no effect of beta-carotene supplementation on development of actinic tumors, malignant or benign [20,22].…”

Section: Pre-2009 Skin Cancer Prevention Trials and Systematic Reviewsmentioning

confidence: 99%

Skin Cancer Prevention: Recent Evidence from Randomized Controlled Trials

et al. 2012

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“…[1][2][3] With the purpose of reducing the effects of UV radiation, diverse molecules have been synthesized to act as radiation filters, diminishing the radiation dose (UVA/ UVB) received by the skin in topical applications. [4][5][6] Recently, the increasing cosmetic use of solar filters has put in evidence the side effects associated with molecules used as photoprotectors. Such effects include photosensitivity reactions, such as allergies and phototoxicity, and constitute a strong limitation for the massive use of these filters; 7 nevertheless, these limitations have encouraged the search J. Braz.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic and photochemical properties of some annulated boldine derivatives

Hidalgo¹,

Alarcón²,

Ojeda³

et al. 2010

J. Braz. Chem. Soc.

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O objetivo deste estudo foi determinar a influência dos grupos substituintes na fotoestabilidade de oito derivados de boldina, incluindo alguns derivados de oxazol e oxazinona, com o propósito de aumentar as propriedades de proteção solar previamente demonstradas para boldina. Tais derivados apresentaram bandas similares à boldina nos espectros de absorção e emissão. As propriedades espectroscópicas são dependentes do pH. A fotoestabilidade dos derivados foi maior que a da boldina, em conformidade com o baixo valor obtido para o rendimento de fotoconsumo quântico. Os baixos valores de rendimento quântico de fluorescência observados para a boldina 1 e 4, tanto na sua forma de base como hidrocloreto, possibilitam postular que esses compostos são desativados por um mecanismo diferente ao da fluorescência, provavelmente devido ao efeito retirador de elétron do grupo NO para a boldina 1 e ao aumento da aromaticidade para a boldina 4.The aim of this study was to determine the influence of the substituent groups on the photostability of eight boldine derivatives, including some oxazole and oxazinone derivatives, in order to increase the sunscreen protection properties previously demonstrated for boldine. Such derivatives showed bands similar to those of boldine in the absorption and emission spectrum. The spectroscopic properties are pH dependent. The photostability of the derivative compounds was higher than that of boldine, in accordance with the low value of the photoconsumption quantum yield determined. The low fluorescence quantum yield values observed for boldine 1 and 4 as both base and hydrochloride derivative compounds led us to postulate that these compounds are deactivated by a mechanism different to the fluorescence pathway, probably due to the electron-withdrawing inductive effect of NO for boldine 1, and to the increase of the aromatic framework for boldine 4.

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A Randomized Controlled Trial to Assess Sunscreen Application and Beta Carotene Supplementation in the Prevention of Solar Keratoses

Cited by 206 publications

References 16 publications

Prevalencia de Queilitis Actínica en Pescadores Artesanales, Valdivia, Chile

Prevalencia de Queilitis Actínica en Pescadores Artesanales, Valdivia, Chile

Skin Cancer Prevention: Recent Evidence from Randomized Controlled Trials

Spectroscopic and photochemical properties of some annulated boldine derivatives

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