A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women

Tartibian, Bakhtyar; FitzGerald, Leah; Azadpour, Noushin; Maleki, Behzad Hajizadeh

doi:10.1177/2053369114565708

Cited by 48 publications

(32 citation statements)

References 42 publications

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“…After deleting duplicates, two reviewers (PTQ and RX) screened titles and abstracts and excluded unrelated records. Finally, 122 full-text articles were examined for eligibility, and 12 studies met the inclusion criteria (Bergström et al, 2009; Muscari et al, 2010; Tartibian et al, 2011, 2015; Friedenreich et al, 2012; Irwin and Olmstead, 2012; Nishida et al, 2015; Abdollahpour et al, 2016; Alghadir et al, 2016; Conroy et al, 2016; Sbardelotto et al, 2017; Mohammadi et al, 2018). One of these 12 studies (Sbardelotto et al, 2017) was excluded, as data remained unavailable, despite attempts to contact the original author.…”

Section: Resultsmentioning

confidence: 99%

Effect of Aerobic Exercise on Inflammatory Markers in Healthy Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zheng

Qiu

Xia

et al. 2019

Front. Aging Neurosci.

140

109

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Background: Chronic inflammation plays a significant role in accelerating the aging process and is closely associated with the initiation and progression of a broad range of age-related diseases. Physical exercise is considered beneficial in alleviating these conditions, but the effects of aerobic exercise on inflammatory markers in a healthy population should be furtherly clarified. Objective: The purpose of this systematic review and meta-analysis was to evaluate the effect of aerobic exercise on inflammatory markers in middle-aged and older adults. Methods: The literature search was conducted utilizing PubMed, Web of Science, Embase, and the Cochrane Library from their inception through April 2018, and the reference lists were screened to identify appropriate studies. Only randomized controlled trials that investigated the effect of aerobic exercise on inflammatory markers in middle-aged and older adults were eligible for this review. Results: Eleven studies involving 1,250 participants were retrieved from the databases for analysis. The pooled results showed that aerobic exercise significantly reduced inflammatory markers (C-reactive protein (CRP): SMD = 0.53, 95% CI 0.26–0.11, p = 0.0002; tumor necrosis factor-alpha (TNF-α): SMD = 0.75, 95% CI 0.31–1.19, p = 0.0007; interleukin 6 (IL-6): SMD = 0.75, 95% CI 0.31–1.19, p = 0.0007). No significant improvement was found in relation to interleukin 4 (IL-4). Conclusions: Aerobic exercise may have a positive effect on reduction of CRP, TNF-α, and IL-6 in middle-aged and older adults. Further randomized controlled trials (RCTs) need to be conducted to determine the effect of aerobic exercise on additional inflammatory markers in the population of middle-aged and older adults.

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Section: Resultsmentioning

confidence: 99%

Effect of Aerobic Exercise on Inflammatory Markers in Healthy Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zheng

Qiu

Xia

et al. 2019

Front. Aging Neurosci.

140

109

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“…Recently, a 3-month randomized trial aerobic exercise training showed reduced plasma concentrations of TNF-α, IL-2 and IL-6 among obese type 2 diabetic patients (Abd El-Kader et al 2013). Likewise, previous studies have also shown decreases in serum C-reactive protein (CRP), prostaglandin (PG) E 2 , TNF-α, IL-6 and IL-8 levels with 16 and 24 weeks of moderate-intensity aerobic exercise training in postmenopausal women (Tartibian et al 2011(Tartibian et al , 2015. Our results indicate that seminal IL-1β, IL-6, IL-8 and TNF-α were significantly attenuated at both 12 and 24 weeks after MICT.…”

Section: Discussionmentioning

confidence: 98%

The effects of three different exercise modalities on markers of male reproduction in healthy subjects: a randomized controlled trial

2017

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The aim of this study was to investigate the effects of moderate-intensity continuous training (MICT), high-intensity continuous training (HICT) and high-intensity interval training (HIIT) on markers of male reproduction including seminal markers of oxidative stress and inflammation as well as semen quality and sperm DNA integrity in healthy human subjects. A total of 397 healthy male volunteers were screened and 280 were randomly assigned to one of the MICT (n = 70), HICT (n = 70), HIIT (n = 70) and non-exercise (NON-EX, n = 70) groups. Subjects had inflammatory markers (IL-1β, IL-6, IL-8 and TNF-α), oxidants (ROS, MDA and 8-isoprostane), antioxidants (SOD, catalase and TAC), semen parameters and sperm DNA damage measured at baseline (T 1 ), the end of week 12 (T 2 ), the end of week 24 (T 3 ), and 7 (T 4 ) and 30 days (T 5 ) after training. Chronic MICT, HICT and HIIT attenuated seminal markers of oxidative stress and inflammation with different kinetics for the three types of exercise (P < 0.05), and these changes were correlated with favorable improvements in semen quality parameters and sperm DNA integrity (P < 0.05). MICT was superior to HICT and HIIT in the improvements of markers of male reproductive function (P < 0.05). In conclusion, different exercise modalities favorably affect markers of male reproduction with different kinetics, suggesting intensity-, duration-and type-dependent adaptations to exercise training in healthy human subjects.Reproduction (2017) 153 157-174

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“…56 Similarly, a randomized controlled study showed that a low-moderate-intensity exercise program resulted in decreased inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), 57 all of which are characteristically elevated in obesity. Other studies, however, have shown that although IL-6 expression may decrease in response to a 16-week brisk walking intervention among sedentary overweight and obese women, it did not result in a favorable impact on the cardiometabolic risk profile irrespective of menopause status.…”

Section: Maintenance Of Weight and Healthy Body Compositionmentioning

confidence: 98%

Menopause and exercise

Grindler

Santoro²

2015

Menopause

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A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women

Abstract: Findings suggest that a low-moderate intensity EX programme decreases cytokines in relation to reproductive hormones in post-menopausal women. These findings support the role of EX in reducing inflammatory markers and improved reproductive hormones in post-menopausal women.

Cited by 48 publications

References 42 publications

Effect of Aerobic Exercise on Inflammatory Markers in Healthy Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effect of Aerobic Exercise on Inflammatory Markers in Healthy Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The effects of three different exercise modalities on markers of male reproduction in healthy subjects: a randomized controlled trial

Menopause and exercise

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