2013
DOI: 10.1097/sla.0b013e3182a4ffa0
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Abstract: Compared with COMP therapy, WB did not reduce transfusion volumes in severely injured patients predicted to receive massive transfusion. However, in the sensitivity analysis (patients without severe brain injuries), use of mWB significantly reduced transfusion volumes, achieving the prespecified endpoint of this initial pilot study.

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Cited by 209 publications
(149 citation statements)
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“…Whole blood is still regularly transfused in military settings, and several ongoing trials [30][31][32][33] are exploring whether the use of fresher blood components or whole blood result in more favorable outcomes; if this research ultimately drives changes in practice and preferential use of such products, it will be critical to define and quantify the risk of TA-GVHD posed by fresh components and determine whether and how it should influence irradiation practices.…”
Section: Org Frommentioning
confidence: 99%
“…Whole blood is still regularly transfused in military settings, and several ongoing trials [30][31][32][33] are exploring whether the use of fresher blood components or whole blood result in more favorable outcomes; if this research ultimately drives changes in practice and preferential use of such products, it will be critical to define and quantify the risk of TA-GVHD posed by fresh components and determine whether and how it should influence irradiation practices.…”
Section: Org Frommentioning
confidence: 99%
“…It is possible that current transfusion strategies can be optimised to further improve survival after ATC [84]; the results of randomised controlled trials will guide further developments [85]. In North America, the challenge of managing ATC has generated renewed interest in whole blood for trauma resuscitation [86][87][88][89]. On the other hand, in some European countries, fibrinogen and other factor concentrates have replaced FFP in the management of ATC [90].…”
Section: The Evolving Importance Of Atc In Trauma Resuscitationmentioning
confidence: 99%
“…Unfortunately, this practice was responsible for an increased risk of transfusion transmittable infections (TTI) [12]. In response, Cotton et al created modified whole blood (MWB) processed through a standard LR filter that does not preserve platelets and transfused the product accompanied by apheresis platelets [13]. The authors demonstrated a significant reduction in blood product utilization in a subgroup of patients with traumatic brain injuries.…”
Section: Discussionmentioning
confidence: 99%