A randomised double-blind crossover trial of the potential analgesic effect of a transdermal nicotine patch in non-smokers based on objective and subjective assessment

Fukada, Tomoko; Iwakiri, Hiroko; Ozaki, Makoto

doi:10.1097/eja.0b013e328347dfd4

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…PV, the system for the quantitative analysis of perception and pain, has recently started to be used in pain clinics [11,12,13,21]. It gives patients an alternative painless sensory stimulation equivalent to pain, mainly by stimulating sensory nerve fibers -Aβ and Aδ-and measures the intensity of the stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…From these perspectives, the PainVision (PV, PS-2100; Nipro Co., Osaka, Japan), a device capable of quantitatively assessing pain intensity by substituting pain with different sensory stimulation, has been developed and is used mainly in pain clinics [10,11,12,13]. In this method, heterogeneous perceptions and senses are aroused by electrical stimulation, and were substituted for pain as felt by a subject, and evaluated quantitatively.…”

Section: Introductionmentioning

confidence: 99%

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Correlations Between Electrically Quantified Pain Degree, Subjectively Assessed Visual Analogue Scale, and the McGill Pain Questionnaire: A Pilot Study

et al. 2014

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ObjectiveTo evaluate the clinical utility of the electrically calculated quantitative pain degree (QPD) and to correlate it with subjective assessments of pain degree including a visual analogue scale (VAS) and the McGill Pain Questionnaire (MPQ).MethodsWe recruited 25 patients with low back pain. Of them, 21 patients suffered from low back pain for more than 3 months. The QPD was calculated using the PainVision (PV, PS-2100; Nipro Co., Osaka, Japan). We applied electrodes to the medial forearm of the subjects and the electrical stimulus was amplified sequentially. Minimum perceived current (MPC) and pain equivalent current (PEC) were defined as minimum electrical stimulation that could be sensed by the subject and electrical stimulation that could trigger actual pain itself. To eliminate individual differences, we defined QPD as the following: QPD=PEC-MPC/MPC. We scored pre-treatment QPD three times at admission and post-treatment QPD once at discharge. The VAS, MPQ, and QPD were evaluated and correlations between the scales were analyzed.ResultsResult showed significant test-retest reliability (ICC=0.967, p<0.001) and the correlation between QDP and MPQ was significant (at admission SRCC=0.619 and p=0.001; at discharge SRCC=0.628, p=0.001). However, the correlation between QPD and VAS was not significant (at admission SRCC=0.240, p=0.248; at discharge SRCC=0.289, p=0.161).ConclusionNumerical values measured with PV showed consistent results with repeated calculations. Electrically measured QPD showed an excellent correlation with MPQ but not with VAS. These results demonstrate that PV is a significantly reliable device for quantifying the intensity of low back pain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlations Between Electrically Quantified Pain Degree, Subjectively Assessed Visual Analogue Scale, and the McGill Pain Questionnaire: A Pilot Study

et al. 2014

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“…The PV was developed in clinical practice for quantitative analysis of pain perception (Matsumura et al 2012; Lee et al 2014; Ohtori et al 2014; Hiraki et al 2014; Kim et al 2014; Fukada et al 2011; Yoshida et al 2015c). PV is an analytical device that was designed to objectively and quantitatively assess patient sense nociception and perception.…”

Section: Introductionmentioning

confidence: 99%

Objective evaluation of oxaliplatin-induced vascular pain secondary to peripheral vein administration

et al. 2016

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BackgroundDuring oxaliplatin chemotherapy administration via a peripheral vein, vascular pain requires changing of the intravenous infusion route on occasion. Vascular pain induced by anticancer drugs reduces the rate of patient continuation and completion of chemotherapy. Pain is presently appraised using subjective methods, such as the visual analog scale (VAS). However, because pain evaluation can vary depending on the physical state and mood of the patient at the time of assessment, it is desirable to evaluate pain objectively. PainVision PS-2100 (PV) is a medical device that was designed to objectively and quantitatively assess patient nociception and perception.MethodsThe present study examined the correlation of subjective and objective assessment of oxaliplatin-induced vascular pain using VAS and PV, respectively.ResultsVascular pain was assessed using both PV and VAS a total of 173 times for 58 colorectal cancer patients. Partial correlation analysis was performed to evaluate the relationship between PV and VAS. The mean PV and VAS scores were 44.5 (range: 0–596) and 24.8 (range: 0–100), respectively. The partial correlation coefficient was 0.408 (p < 0.0001).ConclusionsA strong correlation was not observed between the results, and a weak correlation was observed between VAS and PV scores. Objective evaluation of oxaliplatin-induced vascular pain will be required to help patients overcome vascular pain.

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“…Recently, a quantitative pain-assessing method using electrical stimulation was introduced [12][13][14][15]. PainVision™ devices measure perception threshold and pain produced by an electrical current.…”

Section: Introductionmentioning

confidence: 99%

Development of a Pain Measurement Device Using Electrical Stimulation and Pressure: A Pilot Study

et al. 2018

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Understanding and precise assessment of pain level are key factors in rehabilitation therapy. Pain is a complex and subjective experience that is affected by an individual’s emotion and health conditions. Various methods have been developed for quantitative evaluation of pain level; however, these methods have several drawbacks. In this work, we developed a pain measurement device for quantitative pain assessment. The system consists of two parts, a component for electrical stimulation and a pressure dolorimeter, for application of two different stresses. Regarding electrical stimulation, the degree of pain is assessed by the applied current. Skin resistance was also analyzed by applying current to remove the effects caused by skin conditions. The electrical stimulation did not induce any histological changes or inflammation in the tissues. Using the pressure dolorimeter, the pain level was assessed according to the degree of inflammation. This system could be used for the quantitative assessment of pain induced by inflammation, wounds, and other factors. Since the described system is the first of its kind, there are many problems that remain to be solved. However, with continuous development, our system could provide more accurate pain assessment by removing skin condition effects and through cross-validation.

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A randomised double-blind crossover trial of the potential analgesic effect of a transdermal nicotine patch in non-smokers based on objective and subjective assessment

Abstract: The nicotine patch had no analgesic effect in non-smoking volunteers.

Cited by 11 publications

References 12 publications

Correlations Between Electrically Quantified Pain Degree, Subjectively Assessed Visual Analogue Scale, and the McGill Pain Questionnaire: A Pilot Study

Correlations Between Electrically Quantified Pain Degree, Subjectively Assessed Visual Analogue Scale, and the McGill Pain Questionnaire: A Pilot Study

Objective evaluation of oxaliplatin-induced vascular pain secondary to peripheral vein administration

Development of a Pain Measurement Device Using Electrical Stimulation and Pressure: A Pilot Study

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