A Radiopaque Nanoparticle-Based Ink Using PolyJet 3D Printing for Medical Applications

Shannon, Alice; O'Connell, Aine; O’Sullivan, Aidan; Byrne, Michael E.; Clifford, Seamus; O’Sullivan, Kevin J.; O’Sullivan, Leonard

doi:10.1089/3dp.2019.0160

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…While S. epidermidis was the primary bacteria tested in this study, S. aureus was also strongly inhibited by silver oxide filler in preliminary testing 27 . The 3D printed sample is expected to inhibit growth against S. aureus and potentially MRSA, however, further testing is required to confirm this.…”

Section: Discussionmentioning

confidence: 85%

“…A range of metals and metal oxides were assessed for antimicrobial effects against gram‐positive bacteria, including titanium oxide (248576‐100G, 677469‐5G; Sigma Aldrich, USA), zirconium oxide (230693‐100G, 544760‐5G; Sigma Aldrich, USA), zinc oxide (96479‐100G, 544906‐10G; Sigma Aldrich, USA), magnesium oxide (529699‐10G, 549649‐5G; Sigma Aldrich, USA), silver oxide (226831‐5G; Sigma Aldrich, USA), scandium oxide (307874‐5G; Sigma Aldrich, USA), manganese oxide (217646‐5G; Sigma Aldrich, USA), copper oxide (450812‐25G; Sigma Aldrich, USA), molybdenum oxide (203815‐5G; Sigma Aldrich, USA), tungsten oxide (204781‐10G; Sigma Aldrich, USA), lanthanum oxide (L4000‐100G), silver nanopowder (576832‐5G; Sigma Aldrich, USA), and gold nanopowder (636347‐1G; Sigma Aldrich, USA). The material selection element of this research is described in detail as part of a doctoral thesis 27 . Silver oxide displayed a strong inhibition effect against gram‐positive bacterial growth ( S. epidermidis and S. aureus ) and was used as the antimicrobial filler for this study.…”

Section: Methodsmentioning

confidence: 99%

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Comparing digital light processing and stereolithography vat polymerization Technologies for antimicrobial 3D printing using silver oxide as an antimicrobial filler

Shannon,

Guttridge,

O'Sullivan

et al. 2024

J of Applied Polymer Sci

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Vat polymerization technology allows filler particles to be incorporated into photosensitive 3D printing resin to improve the properties of the printed material. This method can be used to produce medical devices with an antimicrobial effect that can reduce biofilm formation and reduce infections due to indwelling devices. Metal oxides have the potential to combat antibiotic‐resistant bacteria, further lowering the risk of hospital‐acquired infections. The antimicrobial agent in this study, silver oxide, was evaluated for its antimicrobial effect against gram‐positive bacteria (Staphylococcus epidermidis) as these are the main cause of biofilm formation. The 3D printed samples demonstrated a strong antimicrobial effect at low concentrations of 1 wt.%. Two vat polymerization technologies, stereolithography (SLA) and digital light processing (DLP), were compared for their suitability for producing 3D printed samples with an antimicrobial effect. DLP successfully produced samples with mechanical properties comparable to the base resin, whereas SLA samples had reduced mechanical strength at higher concentrations of silver oxide filler. Neither printing technology nor silver oxide concentration had a statistically significant effect on the mechanical properties of the printed materials.

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Section: Discussionmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Comparing digital light processing and stereolithography vat polymerization Technologies for antimicrobial 3D printing using silver oxide as an antimicrobial filler

Shannon,

Guttridge,

O'Sullivan

et al. 2024

J of Applied Polymer Sci

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“…This 3D printing validation run was successful and demonstrated that the material selection matrix had successfully identified a 3D printable radiopaque filler that meets the criteria set out for use in medical applications. The specific details of the formulation and method used for 3D printing this custom resin is described in another journal article and patent, 52,53 and further details of the reduction to practice are detailed in this publication. It must be noted that this research involved modifying the 3D printer and resin cartridges and could potentially affect the machine warranty.…”

Section: Discussionmentioning

confidence: 99%

Assessment and selection of filler compounds for radiopaque PolyJet multi-material 3D printing for use in clinical settings

Shannon

JO'Sullivan

Clifford

et al. 2022

Proc Inst Mech Eng H

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The aim of this research was to assess a selection of radiopaque filler compounds for increasing radiopacity in a resin suitable for Polyjet multi-material 3D printing. A radiopaque resin has potential applications in medicine to produce patient-specific anatomical models with realistic radiological properties, training aids, and skin contacting components such as surgical or procedural guides that require visibility under fluoroscopy. The desirable filler would have a high level of radiopacity under ionising imaging modalities, such as X-ray, CT, fluoroscopy or angiography. Nine potential filler compounds were selected based on atomic number and handling risk: barium sulphate, bismuth oxide, zirconium oxide, strontium oxide, strontium fluoride, strontium carbonate, iodine, niobium oxide and tantalum oxide. The fillers were evaluated using selected criteria. A weighted material selection matrix was developed to prioritise and select a filler for future 3D printing on a multi-material 3D printer. Zirconium oxide was the highest scoring filler compound in the material selection matrix, scoring 4.4 out of a maximum of 5. MED610TM resin doped with zirconium oxide was shown to be UV curable, and when cured is non-toxic, environmentally friendly, and has the ability to display antimicrobial properties. In terms of radiopacity, a sample with thickness 1.5 mm of MED610™ resin doped with 20 wt.% zirconium oxide produced X-ray radiopacity equivalent to 3 mm of aluminium. Zirconium oxide was selected using the material selection matrix. This radiopaque resin can be used to produce anatomical models with accurate radiological properties, training aids or skin contacting devices that require visibility under ionising imaging modalities. The 3D printing validation run successfully demonstrated that the material selection matrix prioritised a filler suitable for radiopaque multi-material 3D printing.

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“…Owing to the radiopaque properties of the loaded zirconium oxide particles, the prepared annulus fibrosus nanofiber scaffolds can be tracked during in vivo scanning and imaging, which enables monitoring of the scaffold position to ensure that ectopia does not occur . This type of scaffold also exhibits good biocompatibility, which effectively solves the problem of unclear imaging in vivo at the initial stage of implantation . However, after long-term implantation, the effect of degradation on radiopaque imaging requires further characterization.…”

Section: Electrospinning Nanofibers For Annulus Fibrosus Scaffoldsmentioning

confidence: 99%

“…52 This type of scaffold also exhibits good biocompatibility, which effectively solves the problem of unclear imaging in vivo at the initial stage of implantation. 53 However, after long-term implantation, the effect of degradation on radiopaque imaging requires further characterization. Table 1 2).…”

Section: Electrospinning Nanofibers For Annulusmentioning

confidence: 99%

Recent Progress in Electrospun Nanofiber-Based Degenerated Intervertebral Disc Repair

Chen

et al. 2021

ACS Biomater. Sci. Eng.

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Annulus fibrosus fissure and fibrosis of nucleus pulposus are severe morphological characteristics of intervertebral disc degeneration. Currently, surgery or drugs are used to relieve pain in such cases. Tissue engineering is a new multidisciplinary strategy with great potential for use in joint replacement and organ regeneration. Based on the natural anatomy of intervertebral discs, intervertebral disc scaffolds are fabricated by exploiting the special arrangement of extracellular matrix fibers. Electrospun nanofibers possess clear advantages in repairing degenerated intervertebral discs. This article reviews and summarizes recently developed methods for improving and fabricating electrospun nanofiber annulus fibrosus scaffolds in terms of nanofiber alignment, material selection, loading additives, and the progress made in combining other advanced technologies with electrospun nanofibers. In addition, the improvement in mechanical properties and biocompatibility of nucleus pulposus scaffolds by electrospun nanofiber-reinforced hydrogels is discussed. Finally, complete intervertebral disc scaffolds can be fabricated using the disc-like angle-ply structure and other emerging fabrication methods. Taken together, electrospun nanofiber intervertebral disc scaffolds are promising for clinical applications.

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A Radiopaque Nanoparticle-Based Ink Using PolyJet 3D Printing for Medical Applications

Cited by 8 publications

References 42 publications

Comparing digital light processing and stereolithography vat polymerization Technologies for antimicrobial 3D printing using silver oxide as an antimicrobial filler

Comparing digital light processing and stereolithography vat polymerization Technologies for antimicrobial 3D printing using silver oxide as an antimicrobial filler

Assessment and selection of filler compounds for radiopaque PolyJet multi-material 3D printing for use in clinical settings

Recent Progress in Electrospun Nanofiber-Based Degenerated Intervertebral Disc Repair

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