A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets

Abstract

A 2 3 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), concentration of binder (C) and the applied pressure (P) on two mechanical properties, namely, tensile strength (TS) and brittle fracture index (BFI), of paracetamol tablets. The factorial design was also used to study the quantitative effects of coprocessing of binders on the mechanical properties. The results obtained from this study suggest that the nature (i.e. plastic/elastic) and ratio of binders coprocessed together alter the influence of C and P on TS and BFI. Utilizou-se planejamento experimental fatorial 2 3 para estudar, quantitativamente, os efeitos individuais e de interação da natureza do ligante (N), concentração do ligante (C) e a pressão aplicada (P) em duas propriedades mecânicas, como forças de ruptura (TS) e índice de fragilidade (BFI) de comprimidos de paracetamol. O planejamento fatorial foi, também, empregado para estudar os efeitos quantitativos do coprocessamento de ligantes nas propriedades mecânicas. Os resultados obtidos desse trabalho sugerem que a natureza (plástica/elástica) e a proporção de ligantes coprocessados, juntas, alteram a influência de C e P em TS e em BFI. Unitermos:Coprocessamento. Goma Neem. Celulose microcristalina. Ligante. Resistência à ruptura. Índice de fragilidade. Paracetamol.

Neem Gum as a Binder in a Formulated Paracetamol Tablet with Reference to Acacia Gum BP

“…Binders are employed in pharmaceutical tablet formulations to provide adequate mechanical properties by promoting the bonding existing between the different components of a powder mix in a formulation thereby enhancing the strength of the eventual tablet produced (2,16,25). Various natural, synthetic, and semi-synthetic substances such as starches, celluloses, and gums have been employed in pharmaceutical tablet formulations as binders (2,4,25).…”

“…Various natural, synthetic, and semi-synthetic substances such as starches, celluloses, and gums have been employed in pharmaceutical tablet formulations as binders (2,4,25). Gum is an example of hydrophilic substances employed in pharmaceutical solid dose formulations mainly as binders and directly compressible excipients (26).…”

“…Although previous studies have evaluated neem gum in one form or the other as a tablet binder (9,25,30), suspending and film coating agent (19,30), or as a directly compressible excipient (26), the present study assessed the activity of neem gum as a binder by evaluating various properties of the granules and tablets prepared with the gum. The flow and compressional properties were used in evaluating the granules while the tablets were assessed by the mechanical property, crushing strength-friability/disintegration time ratio (CSFR/DT) and in vitro drug release profile.…”