A Quantitative Analysis of Drinking Patterns in Alcoholics

Circadian Variation of Ethanol Metabolism in Alcoholics*

“…Thus, he can drink a large amount in the evening without obtaining a much higher blood alcohol level. This finding is consistent with other reports that relatively large amounts of ethanol are required by alcoholics during the late afternoon and evening to maintain established blood alcohol levels (Mello and Mendelson, 1971). When the alcoholic begins to drink again the next day, he may metabolize the ethanol quicker than the previous afternoon and consequently will drink more ethanol.…”

The Performance of Adult Alcoholics Working for Alcohol*: A Detailed Operant Analysis

“…Later during these first two drinking episodes and duruing later episodes, they tended to settle down to lower and more stable drinking rates. Contrary to the data reported by Mello and Mendelson (1971) these subjects often purchased as much as 200 ml of alcohol at a time during these early drinking periods. However, their later rates of drinking did stabilize at levels consistent with those reported by Mello and Mendelson (1971).…”

“…These facts are in general agreement with a large body of literature describing alcohol consumption. These data show shorter drinking episodes than Mello and Mendelson (1971) report, but as pointed out in the introduction, their subjects had sufficient points avaiable at all times.…”

Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling

“…Although average daily blood alcohol concentrations were only moderately high, the levels were highly variable, with day-to-day levels ranging from 0 to over 250 mg/dl (a blood alcohol concentration which can result in severe motor impairment and unconsciousness). The patterns of alcohol consumption and the daily blood alcohol concentrations exhibited by the monkeys in this study are similar to drinking patterns and blood alcohol concentrations of alcoholic men given 24 h/d free access to alcohol for 10–60 consecutive days in a hospital ward [40–42]. …”