A prototype emission-transmission imaging system

Lang, T.F.; Hasegawa, B.H.; Liew, Soo Chin; Brown, J.K.; Blankespoor, S.C.; Reilly, Susan M.; Gingold, Eric L.; Cann, Christopher E.

doi:10.1109/nssmic.1991.259246

Cited by 67 publications

(70 citation statements)

References 7 publications

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“…Recent advances in imaging technology have provided physicians with a new and powerful tool to handle this dilemma: integrated SPECT/CT systems. This work was pioneered by Lang and Hasagawa et al (1), who not only combined hardware components into an integrated system but also developed important algorithms for SPECT attenuation correction using CT images. This technology makes it possible to acquire physiologic and anatomic images in a registered format and fuse them so that precise anatomic localizations of radiopharmaceutical distributions can readily be visualized.…”

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confidence: 99%

SPECT/CT Physical Principles and Attenuation Correction

Patton¹,

Turkington²

2008

Journal of Nuclear Medicine Technology

162

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Using nuclear medicine techniques, physiologic activity and processes can be identified in a way that is unique from other modalities. Oftentimes it is helpful to know the exact location of the physiologic uptake that is visualized on a scan. Knowing the exact location can sometimes help to distinguish normal from abnormal physiologic uptake. When an abnormality has been identified, knowing the exact location can then be helpful in treatment planning. The ability to provide precise localization of physiologic data from nuclear medicine studies is now possible with hybrid SPECT/CT systems. Additionally, these systems provide an accurate attenuation correction of the nuclear medicine image data. After reading this article, the technologist will be able to list and describe the inherent problems associated with SPECT image acquisition and reconstruction, briefly explain how data acquired from the CT scanner are used to provide attenuation correction data for SPECT and anatomic information for diagnostic purposes, list and briefly describe the different types of clinical SPECT/CT systems, and discuss the importance of accurate CT and SPECT image registration. For many years, physicians have been faced with the dilemma of identifying a region of increased uptake on a nuclear medicine image and then trying to determine the precise anatomic location of the region. This is of initial importance in differentiating between abnormal uptake and normal physiologic uptake. Once the determination of abnormal uptake has been established, then it is important for physicians to know the exact anatomic location of the region to determine the proper course of therapy. Recent advances in imaging technology have provided physicians with a new and powerful tool to handle this dilemma: integrated SPECT/CT systems. This work was pioneered by Lang and Hasagawa et al. (1), who not only combined hardware components into an integrated system but also developed important algorithms for SPECT attenuation correction using CT images. This technology makes it possible to acquire physiologic and anatomic images in a registered format and fuse them so that precise anatomic localizations of radiopharmaceutical distributions can readily be visualized. An additional benefit of this technologic advance is that the anatomic images can be used to perform high-quality attenuation corrections of the radiopharmaceutical distributions. To properly acquire these registered images and identify potential pitfalls in the process, it is necessary to have a good working knowledge of the physical principles and instrumentation involved in the data acquisition and image reconstruction processes. SPECTData required for constructing images using the techniques of SPECT are acquired by collecting planar images (typically in 64 · 64 or 128 · 128 data-point arrays) at multiple angles around the patient using single-, dual-, or triple-head scintillation cameras typically equipped with parallel-hole collimators, which provide projection views of the radioactivity from tho...

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confidence: 99%

SPECT/CT Physical Principles and Attenuation Correction

Patton¹,

Turkington²

2008

Journal of Nuclear Medicine Technology

162

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“…This was demonstrated in the first SPECT-CT prototype by Bruce Hasegawa and co-workers [26][27] and has been successfully applied by the first commercial SPECT-CT system [28]. This contradicts Alavi's affirmation [1] that attenuation correction can only be optimal for PET.…”

Section: Will High-resolution/high-sensitivity Spect Ensure That Pet mentioning

confidence: 99%

“…Is it possible that the next months could represent a wonderful tribute to the memory of Bruce Hasegawa [29], who nearly started his research in the field by studying a multipinhole system for the heart [30] (and reinvestigated these systems recently [20,31]) and who invented SPECT-CT [26], through the launch of a commercial multi-pinhole SPECT or SPECT-CT system? We will see, but, whatever happens, thank you and good bye Mister Hasegawa.…”

Section: Will High-resolution/high-sensitivity Spect Ensure That Pet mentioning

confidence: 99%

Will high-resolution/high-sensitivity SPECT ensure that PET is not the only survivor in nuclear medicine during the next decade?

Seret

2009

Eur J Nucl Med Mol Imaging

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“…A prototype for human use was presented as early as in the 1990s [3]. The concept then encouraged further commercial development and the first industry-built systems became available on the market in the late 1990s [4].…”

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confidence: 99%