2018
DOI: 10.1101/271932
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Abstract: Statins reduce plasma cholesterol levels and are effective in secondary cardiovascular disease prevention. However, statin related muscle side effects are a constant problem for patients and doctors because compliance in taking them is severely influenced by the side effects. The mechanism of statin-myopathy remains unknown.We exposed primary human muscle cell lines (n=4) to a lipophilic (simvastatin) and a hydrophilic More than 1800 transcripts and 900 proteins were differentially expressed after exposure to … Show more

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Cited by 2 publications
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References 68 publications
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