A prospective study on clinical profile and incidence of acute kidney injury due to hair dye poisoning

Ramulu, Pradeep Y.; Rao, P. Amruth; Swaroop, Kishan; Marx, K Paul; Devi, Ch. Venkata Ramana

doi:10.18203/2320-6012.ijrms20164194

Int J Res Med Sci

2016

DOI: 10.18203/2320-6012.ijrms20164194

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A prospective study on clinical profile and incidence of acute kidney injury due to hair dye poisoning

Pradeep Y. Ramulu

P. Amruth Rao

Kishan Swaroop

et al.

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“…Similar findings were also noted by Ramulu in his study on 31 patients of alleged hair dye ingestion. 17 In our study, one case of cell oil poisoning with AKI was studied. He was hemodynamically unstable at the time of presentation.…”

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Study of clinical profile and outcome of acute kidney injury in acute poisoning and envenomation

Kumar

Mohan

2018

Int J Adv Med

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Background: Envenomation and poisonings can cause renal damage by number of mechanisms. Some of them may cause rhabdomyolysis or hemolysis, thereby leading pigment induced renal injury. Other contributory factors like shock, sepsis can also cause acute kidney injury (AKI). The study was done with the aim to evaluate the clinical profile and outcome of acute kidney injury in acute poisoning and envenomation and to find the relationship between early anti serum venom (ASV) administration and early presentation to tertiary care and outcome.Methods: This prospective observational study carried out on 50 patients with history of envenomation and poisoning after meeting the requirements of inclusion criteria. History, examination findings and investigations results were collected and analysed.Results: The incidence of AKI in envenomation and poisoning patients was 5.62%. Majority of the toxin induced AKI were due to the poisoning constitutes about 62%. Among them, paraquat (n=15) was the most common poison. snake bites were the commonest to cause AKI in the envenomation group (n=17). The average time between the event and arrival to hospital was 31 hours. Whereas in case of died patients, the average time between the event and arrival to hospital was about 59 hours. The mean time interval between poison consumption to ASV administration in recovered cases was 6.6 hours and in death cases it was 15 hours. Dialysis requirement was in about 43 (86%) patients. Of them 37 patients underwent hemodialysis (HD). 6 patients underwent peritoneal dialysis (PD). Total number of deaths in the study was 26 and the most common cause was respiratory failure (38.5%).Conclusion: The present study suggests the most common cause of AKI in case of envenomation was snake bite and in case of toxin it was paraquat poisoning. Hence it is necessary to take initiative by the government to increase the facilities in primary health care centers to save the lives of the affected people and to impose restrictions on the availability of poisonous substances in the market.

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Study of clinical profile and outcome of acute kidney injury in acute poisoning and envenomation

Kumar

Mohan

2018

Int J Adv Med

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HPLC Detection of Serum and Urinary Paraphenylene Diamine (Ppd) Level and Its Metabolites in Relation to Cardiac Toxicity

Mohamed

aly

Hamed

et al. 2021

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

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Hair dye poisoning is a significant emerging problem in Upper Egypt. The main component of hair dye causing toxicity is para-phenylenediamine (PPD). Ingestion of PPD could be accidental or suicidal. After oral intake, it is metabolized in the liver into N-mono-(MAPPD) and N, N′diacetylated (DAPPD) metabolites. Tissue damage after PPD ingestions occurs due to increased free radical and oxidative stress that depletes tissue glutathione. Cardiac toxicity is a complication of PPD poisoning. It could be manifested by hypotension, different arrhythmia; besides, myocarditis and elevated cardiac biomarkers were also found. Serum and urinary levels of PPD, N-acetyl-p-phenylenediamine (MAPPD), and N--diacetylp-phenylenediamine (DAPPD) were measured by HPLC. A prospective cohort study was planned to determine the relationship between the serum and urinary PPD, N-acetyl-pphenylenediamine (MAPPD) and N, on -diacetyl-p-phenylenediamine (DAPPD) levels with cardiac manifestations of the poisoned patient. Forty patients completed the diagnosis to have acute poisoning following hair dye ingestion. PPD and its metabolite concentrations did not show any significant correlation with the prevalence of cardiac toxicity and could not predict its occurrence among studied patient (p-value< .05

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A prospective study on clinical profile and incidence of acute kidney injury due to hair dye poisoning

Cited by 2 publications

References 9 publications

Study of clinical profile and outcome of acute kidney injury in acute poisoning and envenomation

Study of clinical profile and outcome of acute kidney injury in acute poisoning and envenomation

HPLC Detection of Serum and Urinary Paraphenylene Diamine (Ppd) Level and Its Metabolites in Relation to Cardiac Toxicity

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