A prospective study of the effects of female and male caffeine consumption on the reproductive endpoints of IVF and gamete intra-Fallopian transfer

Klonoff-Cohen, Hillary; Bleha, J.; Lam-Kruglick, Phung

doi:10.1093/humrep/17.7.1746

Cited by 98 publications

(86 citation statements)

References 32 publications

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“…However, there are many environmental factors that may be responsible for observed decreases in sperm quality, independent of age, and that may have significant reproductive consequences, including birth defects (95), cancer (96 -98), and mental disorders (99) in offspring. These environmental insults include cigarette smoking (97, 100), consumption of alcohol (98), and caffeine intake (101). Other environmental factors having a detrimental effect on sperm quality include exposure to industrial chemicals such as phthalates (35) and diagnostic radiation (96).…”

Section: Discussionmentioning

confidence: 99%

Effects of age on DNA double-strand breaks and apoptosis in human sperm

Singh

Müller

Berger

2003

Fertility and Sterility

395

223

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Section: Discussionmentioning

confidence: 99%

Effects of age on DNA double-strand breaks and apoptosis in human sperm

Singh

Müller

Berger

2003

Fertility and Sterility

395

223

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“…Klonoff-Cohen et al reported a higher risk for preterm birth with increasing caffeine intake during pregnancy (15); however, most studies did not find an association between caffeine intake and length of gestation (8,12). Recent dose-response meta-analyses examining the association between prenatal caffeine exposure and risk of adverse pregnancy outcomes indicate that greater caffeine intake during pregnancy may be associated with an increased risk of SA, low birth weight, and small-for-gestational-age infants, but not preterm birth (16,17).…”

Section: Introductionmentioning

confidence: 99%

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

et al. 2017

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“…Caffeine intake was not significantly associated with other outcomes. This was the first IVF/GIFT study to report any effect of caffeine on live births, gestational age, and multiple gestations and if these findings are replicated, caffeine use should be minimized prior to and while undergoing IVF/ GIFT (Klonoff-Cohen et al 2002).…”

Section: Caffeine In Assisted Reproductive Techniquesmentioning

confidence: 89%

Methylxanthines and Reproduction

Minelli

Bellezza

2010

Methylxanthines

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Reproduction is the process by which organisms create descendants. In human reproduction, two kinds of sex cells, or gametes, are involved. Sperm, the male gamete, and egg egg , or ovum ovum Vedi egg , the female gamete, must meet in the female reproductive system to create a new individual and both the female and the male reproductive systems are essential to the occurrence of reproduction. Scientific reports dealing with the effects of methylxanthines on reproduction are mostly centred on the use of these compounds as phosphodiesterase inhibitors that, by maintaining high intracellular levels of cyclic AMP (cAMP) cyclic AMP , will affect the gametes differently. High cAMP levels will sustain sperm sperm maturation while they hold the oocytes in mitotic arrest. Caffeine caffeine , being the methylxanthine most widely consumed by every segment of the population, has been the subject of greatest interest among health professionals and researchers. Conflicting results still seem to characterize the association between male/female caffeine caffeine consumption in adult life and semen quality/fertility fertility , although moderate daily caffeine consumption of levels up to 400-450 mg/day (5.7-6.4 mg/kg/day in a 70-kg adult) do not seem to be associated with adverse effects, i.e. general toxicity, effects on bone status and calcium balance, cardiovascular effects, behavioural changes, increased incidence of cancer, or effects on male fertility. A clear stimulation of egg-laying by the coffee leaf pest Leucoptera coffeella was recently reported, providing support for the hypothesis that caffeine, in a dose-dependent way, in insects stimulates egg-laying, thus leading to the death of coffee trees.

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A prospective study of the effects of female and male caffeine consumption on the reproductive endpoints of IVF and gamete intra-Fallopian transfer

Abstract: This is the first IVF/GIFT study to report any effect of caffeine on live births, gestational age, and multiple gestations. If these findings are replicated, caffeine use should be minimized prior to and while undergoing IVF/GIFT.

Cited by 98 publications

References 32 publications

Effects of age on DNA double-strand breaks and apoptosis in human sperm

Effects of age on DNA double-strand breaks and apoptosis in human sperm

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

Methylxanthines and Reproduction

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