A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer

Klonoff-Cohen, Hillary; Chu, Elaine; Natarajan, Loki; Sieber, William J.

doi:10.1016/s0015-0282(01)02008-8

Cited by 329 publications

(194 citation statements)

References 47 publications

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“…Our data are in agreement with those of previous studies in which women undergoing IVF treatment often experienced high levels of psychological stress, anxiety and depression. 4,11,12 However, our study is in contrast with other studies where the authors reported that women entering an IVF-program are, in general psychologically well adjusted. 13,14 In relation to RM, our study results are comparable to previous studies showing positive link of stress and miscarriage.…”

Section: Discussioncontrasting

confidence: 94%

Stress in women with Reproductive Failure

Bhandari

2016

Nepal j. obstet. gynaecol.

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Aims: The study aim to measure the level of stress in women with recurrent miscarriage and infertile women undergoing in-vitro fertilization treatment using psychological, endocrinological and immunological markers of stress.Methods: Group A（Recurrent Miscarriage Group, RM Group） of 20 women who had had at least three or more consecutive spontaneous abortions after negative biomedical diagnostic screening test; Group B (Infertility Group) of 40 infertile women undergoing in-vitro fertilization treatment after down-regulation with Gonadotropin-releasing Hormone (GnRH) agonist in a long protocol and Group C (Control Group) of 15 fertile women were asked to complete the stress questionnaires : the Perceived stress scale (PSS), the Fertility Problem Inventory (FPI), the Positive and Negative Scale (PANAS) and the SF-12 Health Survey. Blood samples were collected to measure natural killer (NK) cells and cortisol levels.Results: The score of stress questionnaires were significantly high in women with reproductive failure compared to fertile control group (p=0.023 for PSS; p=0.011 for FPI; p=0.013 for negative scale of PANAS) and the score of MCS from SF-12 Health Survey was significantly lower compared to control group (p=0.001). However, no significant differences were seen between women with RM and infertile women undergoing IVF treatment. Women with reproductive failure have increased number of peripheral NK cells compared to controls (p=0.000). No significant difference was found in the serum cortisol level between the women with reproductive failure and fertile women.Conclusions: Women with reproductive failure perceived higher levels of psychological stress. Level of stress in women with recurrent miscarriage is comparable to that of infertile women undergoing in-vitro fertilization treatment. Increased numbers of NK cells were found in the peripheral blood of women with reproductive failure.

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Section: Discussioncontrasting

confidence: 94%

Stress in women with Reproductive Failure

Bhandari

2016

Nepal j. obstet. gynaecol.

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“…These are related to a number of stresses that are the results of both the diagnosis and treatment of infertility [7]. Furthermore, IVF is usually the final treatment option for infertile couples, and the unpredictable outcome of the IVF treatment may induce a depressive mood [3,5,7].…”

mentioning

confidence: 99%

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Eryılmaz

Devran

Sarıkaya

et al. 2011

J Assist Reprod Genet

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Purpose We aimed to analyse the in vitro fertilizationembryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin. Methods A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups. Results Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively. Conclusion IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

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“…Previous studies employing psychometric measures, biological stress measures, or both have reported varied, and often conflicting, results for associations between psychological stress and IVF outcomes [5,13,14,[23][24][25][26]. Infertility, as well as its treatment, can be considered significant chronic stressors, but the neuroendocrine components of this response and the extent to which environmental contaminants modulate this are unclear.…”

Section: Discussionmentioning

confidence: 99%

Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men

Butts

Bloom

Frye

et al. 2014

J Assist Reprod Genet

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Purpose Our primary objective was to assess associations between urine cortisol as a biomarker of psychological stress and in vitro fertilization (IVF) outcomes. A secondary objective was to assess associations between toxic metals and cortisol. Methods Urine and blood specimens were collected from 52 women and 28 male partners completing a first IVF procedure, on the day of oocyte retrieval. Urine cortisol was measured with an enzyme-linked immunosorbent assay. Mercury (Hg), cadmium (Cd), and lead (Pb) were determined in blood and Cd in urine by inductively coupled plasma-mass spectrometry.Results No associations were indicated for cortisol with IVF outcomes in multivariable regression models adjusted for covariates. However, we detected positive linear associations for cortisol and urine Cd (β=9.96, 95%CI 1.52, 21.44) and blood Hg (β=1.44, 95%CI 0.31, 3.18). An exploratory stratified analysis suggested a potential inverse association between urine cortisol and oocyte fertilization among women with low, but not high blood Hg. Conclusion While limited, these preliminary data suggest that psychological stress may not play a major role in IVF outcomes, which therefore could be one less concern for couples and their clinicians. Our data also raise the possibility for toxic metals to modify associations between cortisol and IVF outcomes among women. However, these preliminary results require corroboration in an experimental animal model and confirmation in a larger, more definitive observational study.

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A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer

Cited by 329 publications

References 47 publications

Stress in women with Reproductive Failure

Stress in women with Reproductive Failure

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men

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