A Prospective Study of Autistic-Like Traits in Unaffected Siblings of Probands With Autism Spectrum Disorder

Early behavioral profiles elucidating vulnerability and resiliency to later ASD outcomes

“…Our finding of two clusters, one large and one small, in the current study including children with and without outcome diagnosis of ASD at the juncture between the prodromal and symptom emergence periods of ASD aligns with the finding of two clusters by Georgiades et al (2013). Yet some major differences exist.…”

Heterogeneity of subclinical autistic traits among parents of children with autism spectrum disorder: Identifying the broader autism phenotype with a data‐driven method

“…The percentage of parents of children with ASD allocated to the BAP cluster were consistent with findings of previous studies using arbitrary cut‐off scores [Ruta et al, ; Sasson et al, ; Wheelright et al, 2010]. It seems that phenotypic characteristics of BAP can be detectable in approximately one fifth of first‐degree relatives of individuals with ASD in adults, as well as in childhood [Georgides et al, ]. Our findings were also generally similar to finding of Ruzich et al [] which explored autistic traits subgroups with hierarchical clustering in siblings of individuals with ASD.…”

Quantifying Repetitive Hand Flapping Kinematics in Autistic and Non‐Autistic Toddlers Using Video‐Based Pose Estimation

“…For example, in a multisite cohort study, approximately 19% of infants at elevated likelihood for autism, who did not receive an autism diagnosis by age 3 years, were identified at 12 months as exhibiting a relatively high level of autism-related behaviors. These same infants later showed decreased social communication abilities at age 3 years (Georgiades et al 2013 ). Consistent with our findings, Georgiades et al reported only a small, nonsignificant difference in the parent -report ADI -R repetitive behaviors domain at age 3 between groups ( ES = 0.28, p = 0.11).…”