A Prospective Study of Aspirin Use and Cataract Extraction in Women

Crude and standardized prevalences of cataract and related factors in the elderly people in Northern Iran

“…No protective effect of aspirin consumption for at least 20 years was found in that study. 23 That was in keeping with our study in which no effect of aspirin was observed in multivariate regression models. However, in univariate analysis, a significant effect was observed.…”

“…However, in univariate analysis, a significant effect was observed. It should be noted that the Hankinson and colleagues’ 23 study was a prospective cohort which was expected to be more reliable than our cross-sectional study. In total, evidences regarding the protective effect of aspirin were low according to our comprehensive search.…”

“…Results of previous studies reporting the related factors of cataract are presented in Table 3. 13,15,21,23–29 In the study conducted by Hankinson and colleagues (nurses health cohort), during 434,680-person-year follow-up, 448 patients with cataract were diagnosed. No protective effect of aspirin consumption for at least 20 years was found in that study.…”

Crude and standardized prevalences of cataract and related factors in the elderly people in Northern Iran

“…No protective effect of aspirin consumption for at least 20 years was found in that study. 23 That was in keeping with our study in which no effect of aspirin was observed in multivariate regression models. However, in univariate analysis, a significant effect was observed.…”

“…However, in univariate analysis, a significant effect was observed. It should be noted that the Hankinson and colleagues’ 23 study was a prospective cohort which was expected to be more reliable than our cross-sectional study. In total, evidences regarding the protective effect of aspirin were low according to our comprehensive search.…”

“…Results of previous studies reporting the related factors of cataract are presented in Table 3. 13,15,21,23–29 In the study conducted by Hankinson and colleagues (nurses health cohort), during 434,680-person-year follow-up, 448 patients with cataract were diagnosed. No protective effect of aspirin consumption for at least 20 years was found in that study.…”

Drug repurposing for reducing the risk of cataract extraction in patients with diabetes mellitus: integration of artificial intelligence-based drug prediction and clinical corroboration

“…Our results are also consistent with those of a clinical trial evaluating aspirin in DM cataract patients with rheumatoid arthritis ( Cotlier, 1981 ), in addition to several clinical trials ( Heyningen and Harding, 1986 ; Harding et al, 1989 ; Klein et al, 2001 ), further suggesting possible protective mechanisms of aspirin against cataract extraction. However, several other studies report no significant reduction in cataract extraction for patients taking aspirin ( Klein et al, 1987 ; Seddon et al, 1991 ; Hankinson et al, 1993 ; Christen et al, 2001 ). Many such studies focus on aspirin for a wide patient population, not just those with DM, so our finding that aspirin reduces the risk of cataract extraction in DM patients with pain, inflammation, or rheumatoid arthritis should not be extrapolated to all patients with cataracts.…”

Risk Factors Associated with Incident Cataracts and Cataract Surgery in the Age-Related Eye Disease Study (AREDS)

“…46–48,57,58 In an earlier case-control analysis of baseline risk factor associations with cataract in the AREDS, a decreased risk of nuclear cataract was associated with NSAIDs, including aspirin, and an increased risk of cortical cataract was associated with thyroid hormone use. 25 In the current analysis, however, NSAIDs were associated with increased risk of cataract surgery, but not with any specific opacity type, and thyroid hormone use was associated with increased risk of PSC cataract, but not cortical cataract.…”

Crude and standardized prevalences of cataract and related factors in the elderly people in Northern Iran

“…No protective effect of aspirin consumption for at least 20 years was found in that study. 23 That was in keeping with our study in which no effect of aspirin was observed in multivariate regression models. However, in univariate analysis, a significant effect was observed.…”

“…However, in univariate analysis, a significant effect was observed. It should be noted that the Hankinson and colleagues’ 23 study was a prospective cohort which was expected to be more reliable than our cross-sectional study. In total, evidences regarding the protective effect of aspirin were low according to our comprehensive search.…”

“…Results of previous studies reporting the related factors of cataract are presented in Table 3. 13,15,21,23–29 In the study conducted by Hankinson and colleagues (nurses health cohort), during 434,680-person-year follow-up, 448 patients with cataract were diagnosed. No protective effect of aspirin consumption for at least 20 years was found in that study.…”

Drug repurposing for reducing the risk of cataract extraction in patients with diabetes mellitus: integration of artificial intelligence-based drug prediction and clinical corroboration

“…Our results are also consistent with those of a clinical trial evaluating aspirin in DM cataract patients with rheumatoid arthritis ( Cotlier, 1981 ), in addition to several clinical trials ( Heyningen and Harding, 1986 ; Harding et al, 1989 ; Klein et al, 2001 ), further suggesting possible protective mechanisms of aspirin against cataract extraction. However, several other studies report no significant reduction in cataract extraction for patients taking aspirin ( Klein et al, 1987 ; Seddon et al, 1991 ; Hankinson et al, 1993 ; Christen et al, 2001 ). Many such studies focus on aspirin for a wide patient population, not just those with DM, so our finding that aspirin reduces the risk of cataract extraction in DM patients with pain, inflammation, or rheumatoid arthritis should not be extrapolated to all patients with cataracts.…”

Risk Factors Associated with Incident Cataracts and Cataract Surgery in the Age-Related Eye Disease Study (AREDS)

“…46–48,57,58 In an earlier case-control analysis of baseline risk factor associations with cataract in the AREDS, a decreased risk of nuclear cataract was associated with NSAIDs, including aspirin, and an increased risk of cortical cataract was associated with thyroid hormone use. 25 In the current analysis, however, NSAIDs were associated with increased risk of cataract surgery, but not with any specific opacity type, and thyroid hormone use was associated with increased risk of PSC cataract, but not cortical cataract.…”

Crude and standardized prevalences of cataract and related factors in the elderly people in Northern Iran

“…No protective effect of aspirin consumption for at least 20 years was found in that study. 23 That was in keeping with our study in which no effect of aspirin was observed in multivariate regression models. However, in univariate analysis, a significant effect was observed.…”

“…However, in univariate analysis, a significant effect was observed. It should be noted that the Hankinson and colleagues’ 23 study was a prospective cohort which was expected to be more reliable than our cross-sectional study. In total, evidences regarding the protective effect of aspirin were low according to our comprehensive search.…”

“…Results of previous studies reporting the related factors of cataract are presented in Table 3. 13,15,21,23–29 In the study conducted by Hankinson and colleagues (nurses health cohort), during 434,680-person-year follow-up, 448 patients with cataract were diagnosed. No protective effect of aspirin consumption for at least 20 years was found in that study.…”

Drug repurposing for reducing the risk of cataract extraction in patients with diabetes mellitus: integration of artificial intelligence-based drug prediction and clinical corroboration

“…Our results are also consistent with those of a clinical trial evaluating aspirin in DM cataract patients with rheumatoid arthritis ( Cotlier, 1981 ), in addition to several clinical trials ( Heyningen and Harding, 1986 ; Harding et al, 1989 ; Klein et al, 2001 ), further suggesting possible protective mechanisms of aspirin against cataract extraction. However, several other studies report no significant reduction in cataract extraction for patients taking aspirin ( Klein et al, 1987 ; Seddon et al, 1991 ; Hankinson et al, 1993 ; Christen et al, 2001 ). Many such studies focus on aspirin for a wide patient population, not just those with DM, so our finding that aspirin reduces the risk of cataract extraction in DM patients with pain, inflammation, or rheumatoid arthritis should not be extrapolated to all patients with cataracts.…”

Risk Factors Associated with Incident Cataracts and Cataract Surgery in the Age-Related Eye Disease Study (AREDS)

“…46–48,57,58 In an earlier case-control analysis of baseline risk factor associations with cataract in the AREDS, a decreased risk of nuclear cataract was associated with NSAIDs, including aspirin, and an increased risk of cortical cataract was associated with thyroid hormone use. 25 In the current analysis, however, NSAIDs were associated with increased risk of cataract surgery, but not with any specific opacity type, and thyroid hormone use was associated with increased risk of PSC cataract, but not cortical cataract.…”